| http://purl.uniprot.org/citations/25605781 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25605781 | http://www.w3.org/2000/01/rdf-schema#comment | "The primary glial cells in the retina, the Müller glia, differentiate from retinal progenitors in the first postnatal week. CNTF/LIF/STAT3 signaling has been shown to promote their differentiation; however, another key glial differentiation signal, BMP, has not been examined during this period of Müller glial differentiation. In the course of our analysis of the BMP signaling pathway, we observed a transient wave of Smad1/5/8 signaling in the inner nuclear layer at the end of the first postnatal week, from postnatal day (P) 5 to P9, after the end of neurogenesis. To determine the function of this transient wave, we blocked BMP signaling during this period in vitro or in vivo, using either a BMP receptor antagonist or noggin (Nog). Either treatment leads to a reduction in expression of the Müller glia-specific genes Rlbp1 and Glul, and the failure of many of the Müller glia to repress the bipolar/photoreceptor gene Otx2. These changes in normal Müller glial differentiation result in permanent disruption of the retina, including defects in the outer limiting membrane, rosette formation and a reduction in functional acuity. Our results thus show that Müller glia require a transient BMP signal at the end of neurogenesis to fully repress the neural gene expression program and to promote glial gene expression."xsd:string |
| http://purl.uniprot.org/citations/25605781 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.118745"xsd:string |
| http://purl.uniprot.org/citations/25605781 | http://purl.uniprot.org/core/author | "Ueki Y."xsd:string |
| http://purl.uniprot.org/citations/25605781 | http://purl.uniprot.org/core/author | "Bermingham-McDonogh O."xsd:string |
| http://purl.uniprot.org/citations/25605781 | http://purl.uniprot.org/core/author | "Reh T.A."xsd:string |
| http://purl.uniprot.org/citations/25605781 | http://purl.uniprot.org/core/author | "Wilken M.S."xsd:string |
| http://purl.uniprot.org/citations/25605781 | http://purl.uniprot.org/core/author | "Cox K.E."xsd:string |
| http://purl.uniprot.org/citations/25605781 | http://purl.uniprot.org/core/author | "Chipman L.B."xsd:string |
| http://purl.uniprot.org/citations/25605781 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25605781 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/25605781 | http://purl.uniprot.org/core/pages | "533-543"xsd:string |
| http://purl.uniprot.org/citations/25605781 | http://purl.uniprot.org/core/title | "A transient wave of BMP signaling in the retina is necessary for Muller glial differentiation."xsd:string |
| http://purl.uniprot.org/citations/25605781 | http://purl.uniprot.org/core/volume | "142"xsd:string |
| http://purl.uniprot.org/citations/25605781 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25605781 |
| http://purl.uniprot.org/citations/25605781 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25605781 |
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| http://purl.uniprot.org/uniprot/#_A0A0U1RQ07-mappedCitation-25605781 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25605781 |
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