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| http://purl.uniprot.org/citations/25607232 | http://www.w3.org/2000/01/rdf-schema#comment | "CEP161 is a novel component of the Dictyostelium discoideum centrosome which was identified as binding partner of the pericentriolar component CP250. Here we show that the amino acids 1-763 of the 1381 amino acids CEP161 are sufficient for CP250 binding, centrosomal targeting and centrosome association. Analysis of AX2 cells over-expressing truncated and full length CEP161 proteins revealed defects in growth and development. By immunoprecipitation experiments we identified the Hippo related kinase SvkA (Hrk-svk) as binding partner for CEP161. Both proteins colocalize at the centrosome. In in vitro kinase assays the N-terminal domain of CEP161 (residues 1-763) inhibited the kinase activity of Hrk-svk. A comparison of D. discoideum Hippo kinase mutants with mutants overexpressing CEP161 polypeptides revealed similar defects. We propose that the centrosomal component CEP161 is a novel player in the Hippo signaling pathway and affects various cellular properties through this interaction."xsd:string |
| http://purl.uniprot.org/citations/25607232 | http://purl.org/dc/terms/identifier | "doi:10.1080/15384101.2015.1007015"xsd:string |
| http://purl.uniprot.org/citations/25607232 | http://purl.uniprot.org/core/author | "Noegel A.A."xsd:string |
| http://purl.uniprot.org/citations/25607232 | http://purl.uniprot.org/core/author | "Schleicher M."xsd:string |
| http://purl.uniprot.org/citations/25607232 | http://purl.uniprot.org/core/author | "Rohlfs M."xsd:string |
| http://purl.uniprot.org/citations/25607232 | http://purl.uniprot.org/core/author | "Sukumaran S.K."xsd:string |
| http://purl.uniprot.org/citations/25607232 | http://purl.uniprot.org/core/author | "Gallinger C."xsd:string |
| http://purl.uniprot.org/citations/25607232 | http://purl.uniprot.org/core/author | "Blau-Wasser R."xsd:string |
| http://purl.uniprot.org/citations/25607232 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25607232 | http://purl.uniprot.org/core/name | "Cell Cycle"xsd:string |
| http://purl.uniprot.org/citations/25607232 | http://purl.uniprot.org/core/pages | "1024-1035"xsd:string |
| http://purl.uniprot.org/citations/25607232 | http://purl.uniprot.org/core/title | "The centrosomal component CEP161 of Dictyostelium discoideum interacts with the Hippo signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/25607232 | http://purl.uniprot.org/core/volume | "14"xsd:string |
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