| http://purl.uniprot.org/citations/25621951 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25621951 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25621951 | http://www.w3.org/2000/01/rdf-schema#comment | "Multiple lines of evidence indicate that mitochondrial dysfunction is central to Parkinson's disease. Here we investigate the mechanism by which parkin, an E3 ubiquitin ligase, and USP30, a mitochondrion-localized deubiquitylase, regulate mitophagy. We find that mitochondrial damage stimulates parkin to assemble Lys 6, Lys 11 and Lys 63 chains on mitochondria, and that USP30 is a ubiquitin-specific deubiquitylase with a strong preference for cleaving Lys 6- and Lys 11-linked multimers. Using mass spectrometry, we show that recombinant USP30 preferentially removes these linkage types from intact ubiquitylated mitochondria and counteracts parkin-mediated ubiquitin chain formation in cells. These results, combined with a series of chimaera and localization studies, afford insights into the mechanism by which a balance of ubiquitylation and deubiquitylation regulates mitochondrial homeostasis, and suggest a general mechanism for organelle autophagy."xsd:string |
| http://purl.uniprot.org/citations/25621951 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb3097"xsd:string |
| http://purl.uniprot.org/citations/25621951 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb3097"xsd:string |
| http://purl.uniprot.org/citations/25621951 | http://purl.uniprot.org/core/author | "Corn J.E."xsd:string |
| http://purl.uniprot.org/citations/25621951 | http://purl.uniprot.org/core/author | "Corn J.E."xsd:string |
| http://purl.uniprot.org/citations/25621951 | http://purl.uniprot.org/core/author | "Yu C."xsd:string |
| http://purl.uniprot.org/citations/25621951 | http://purl.uniprot.org/core/author | "Yu C."xsd:string |
| http://purl.uniprot.org/citations/25621951 | http://purl.uniprot.org/core/author | "Kirkpatrick D.S."xsd:string |
| http://purl.uniprot.org/citations/25621951 | http://purl.uniprot.org/core/author | "Kirkpatrick D.S."xsd:string |
| http://purl.uniprot.org/citations/25621951 | http://purl.uniprot.org/core/author | "Phu L."xsd:string |
| http://purl.uniprot.org/citations/25621951 | http://purl.uniprot.org/core/author | "Phu L."xsd:string |
| http://purl.uniprot.org/citations/25621951 | http://purl.uniprot.org/core/author | "Baughman J.M."xsd:string |
| http://purl.uniprot.org/citations/25621951 | http://purl.uniprot.org/core/author | "Baughman J.M."xsd:string |
| http://purl.uniprot.org/citations/25621951 | http://purl.uniprot.org/core/author | "Bingol B."xsd:string |
| http://purl.uniprot.org/citations/25621951 | http://purl.uniprot.org/core/author | "Bingol B."xsd:string |
| http://purl.uniprot.org/citations/25621951 | http://purl.uniprot.org/core/author | "Coons M."xsd:string |
| http://purl.uniprot.org/citations/25621951 | http://purl.uniprot.org/core/author | "Coons M."xsd:string |
| http://purl.uniprot.org/citations/25621951 | http://purl.uniprot.org/core/author | "Cunningham C.N."xsd:string |
| http://purl.uniprot.org/citations/25621951 | http://purl.uniprot.org/core/author | "Cunningham C.N."xsd:string |
| http://purl.uniprot.org/citations/25621951 | http://purl.uniprot.org/core/author | "Tea J.S."xsd:string |
| http://purl.uniprot.org/citations/25621951 | http://purl.uniprot.org/core/author | "Tea J.S."xsd:string |
| http://purl.uniprot.org/citations/25621951 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25621951 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |