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| http://purl.uniprot.org/citations/25625329 | http://www.w3.org/2000/01/rdf-schema#comment | "tRNA modifications are crucial for efficient and accurate protein translation, with defects often linked to disease. There are 7 cytoplasmic tRNA modifications in the yeast Saccharomyces cerevisiae that are formed by an enzyme consisting of a catalytic subunit and an auxiliary protein, 5 of which require only a single subunit in bacteria, and 2 of which are not found in bacteria. These enzymes include the deaminase Tad2-Tad3, and the methyltransferases Trm6-Trm61, Trm8-Trm82, Trm7-Trm732, and Trm7-Trm734, Trm9-Trm112, and Trm11-Trm112. We describe the occurrence and biological role of each modification, evidence for a required partner protein in S. cerevisiae and other eukaryotes, evidence for a single subunit in bacteria, and evidence for the role of the non-catalytic binding partner. Although it is unclear why these eukaryotic enzymes require partner proteins, studies of some 2-subunit modification enzymes suggest that the partner proteins help expand substrate range or allow integration of cellular activities."xsd:string |
| http://purl.uniprot.org/citations/25625329 | http://purl.org/dc/terms/identifier | "doi:10.1080/15476286.2015.1008360"xsd:string |
| http://purl.uniprot.org/citations/25625329 | http://purl.uniprot.org/core/author | "Phizicky E.M."xsd:string |
| http://purl.uniprot.org/citations/25625329 | http://purl.uniprot.org/core/author | "Guy M.P."xsd:string |
| http://purl.uniprot.org/citations/25625329 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25625329 | http://purl.uniprot.org/core/name | "RNA Biol"xsd:string |
| http://purl.uniprot.org/citations/25625329 | http://purl.uniprot.org/core/pages | "1608-1618"xsd:string |
| http://purl.uniprot.org/citations/25625329 | http://purl.uniprot.org/core/title | "Two-subunit enzymes involved in eukaryotic post-transcriptional tRNA modification."xsd:string |
| http://purl.uniprot.org/citations/25625329 | http://purl.uniprot.org/core/volume | "11"xsd:string |
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