| http://purl.uniprot.org/citations/25631044 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25631044 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25631044 | http://www.w3.org/2000/01/rdf-schema#comment | "Coenzyme Q (Q or ubiquinone) is a redox active lipid composed of a fully substituted benzoquinone ring and a polyisoprenoid tail and is required for mitochondrial electron transport. In the yeast Saccharomyces cerevisiae, Q is synthesized by the products of 11 known genes, COQ1-COQ9, YAH1, and ARH1. The function of some of the Coq proteins remains unknown, and several steps in the Q biosynthetic pathway are not fully characterized. Several of the Coq proteins are associated in a macromolecular complex on the matrix face of the inner mitochondrial membrane, and this complex is required for efficient Q synthesis. Here, we further characterize this complex via immunoblotting and proteomic analysis of tandem affinity-purified tagged Coq proteins. We show that Coq8, a putative kinase required for the stability of the Q biosynthetic complex, is associated with a Coq6-containing complex. Additionally Q6 and late stage Q biosynthetic intermediates were also found to co-purify with the complex. A mitochondrial protein of unknown function, encoded by the YLR290C open reading frame, is also identified as a constituent of the complex and is shown to be required for efficient de novo Q biosynthesis. Given its effect on Q synthesis and its association with the biosynthetic complex, we propose that the open reading frame YLR290C be designated COQ11."xsd:string |
| http://purl.uniprot.org/citations/25631044 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m114.633131"xsd:string |
| http://purl.uniprot.org/citations/25631044 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m114.633131"xsd:string |
| http://purl.uniprot.org/citations/25631044 | http://purl.uniprot.org/core/author | "Wang C."xsd:string |
| http://purl.uniprot.org/citations/25631044 | http://purl.uniprot.org/core/author | "Wang C."xsd:string |
| http://purl.uniprot.org/citations/25631044 | http://purl.uniprot.org/core/author | "Loo J.A."xsd:string |
| http://purl.uniprot.org/citations/25631044 | http://purl.uniprot.org/core/author | "Loo J.A."xsd:string |
| http://purl.uniprot.org/citations/25631044 | http://purl.uniprot.org/core/author | "Merchant S.S."xsd:string |
| http://purl.uniprot.org/citations/25631044 | http://purl.uniprot.org/core/author | "Merchant S.S."xsd:string |
| http://purl.uniprot.org/citations/25631044 | http://purl.uniprot.org/core/author | "Johnson J.S."xsd:string |
| http://purl.uniprot.org/citations/25631044 | http://purl.uniprot.org/core/author | "Johnson J.S."xsd:string |
| http://purl.uniprot.org/citations/25631044 | http://purl.uniprot.org/core/author | "Allan C.M."xsd:string |
| http://purl.uniprot.org/citations/25631044 | http://purl.uniprot.org/core/author | "Allan C.M."xsd:string |
| http://purl.uniprot.org/citations/25631044 | http://purl.uniprot.org/core/author | "Awad A.M."xsd:string |
| http://purl.uniprot.org/citations/25631044 | http://purl.uniprot.org/core/author | "Awad A.M."xsd:string |
| http://purl.uniprot.org/citations/25631044 | http://purl.uniprot.org/core/author | "Blaby-Haas C.E."xsd:string |
| http://purl.uniprot.org/citations/25631044 | http://purl.uniprot.org/core/author | "Blaby-Haas C.E."xsd:string |
| http://purl.uniprot.org/citations/25631044 | http://purl.uniprot.org/core/author | "Clarke C.F."xsd:string |
| http://purl.uniprot.org/citations/25631044 | http://purl.uniprot.org/core/author | "Clarke C.F."xsd:string |
| http://purl.uniprot.org/citations/25631044 | http://purl.uniprot.org/core/author | "Shirasaki D.I."xsd:string |
| http://purl.uniprot.org/citations/25631044 | http://purl.uniprot.org/core/author | "Shirasaki D.I."xsd:string |
| http://purl.uniprot.org/citations/25631044 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25631044 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |