| http://purl.uniprot.org/citations/25635767 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25635767 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25635767 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25635767 | http://www.w3.org/2000/01/rdf-schema#comment | "Adamantanes and neuraminidase inhibitors (NAIs) are two classes of antiviral drugs available for the chemoprophylaxis and treatment of influenza infections. To determine the frequency of drug resistance in influenza A/H3N2 viruses in Singapore, large-scale sequencing of neuraminidase (NA) and matrix protein (MP) genes was performed directly without initial culture amplification. 241 laboratory-confirmed influenza A/H3N2 clinical samples, collected between May 2009 and November 2013 were included. In total, 229 NA (95%) and 241 MP (100%) complete sequences were obtained. Drug resistance mutations in the NA and MP genes were interpreted according to published studies. For the NAIs, a visual inspection of the aligned NA sequences revealed no known drug resistant genotypes (DRGs). For the adamantanes, the well-recognised S31N DRG was identified in all 241 MP genes. In addition, there was an increasing number of viruses carrying the combination of D93G+Y155F+D251V (since May 2013) or D93G (since March 2011) mutations in the NA gene. However, in-vitro NAI testing indicated that neither D93G+Y155F+D251V nor D93G alone conferred any changes in NAI susceptibility. Lastly, an I222T mutation in the NA gene that has previously been reported to cause oseltamivir-resistance in influenza A/H1N1/2009, B, and A/H5N1, was detected from a treatment-naïve patient. Further in-vitro NAI testing is required to confirm the effect of this mutation in A/H3N2 virus."xsd:string |
| http://purl.uniprot.org/citations/25635767 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0117822"xsd:string |
| http://purl.uniprot.org/citations/25635767 | http://purl.uniprot.org/core/author | "Lee H.K."xsd:string |
| http://purl.uniprot.org/citations/25635767 | http://purl.uniprot.org/core/author | "Lee H.K."xsd:string |
| http://purl.uniprot.org/citations/25635767 | http://purl.uniprot.org/core/author | "Lee H.K."xsd:string |
| http://purl.uniprot.org/citations/25635767 | http://purl.uniprot.org/core/author | "Tang J.W."xsd:string |
| http://purl.uniprot.org/citations/25635767 | http://purl.uniprot.org/core/author | "Tang J.W."xsd:string |
| http://purl.uniprot.org/citations/25635767 | http://purl.uniprot.org/core/author | "Tang J.W."xsd:string |
| http://purl.uniprot.org/citations/25635767 | http://purl.uniprot.org/core/author | "Koay E.S."xsd:string |
| http://purl.uniprot.org/citations/25635767 | http://purl.uniprot.org/core/author | "Koay E.S."xsd:string |
| http://purl.uniprot.org/citations/25635767 | http://purl.uniprot.org/core/author | "Koay E.S."xsd:string |
| http://purl.uniprot.org/citations/25635767 | http://purl.uniprot.org/core/author | "Hurt A.C."xsd:string |
| http://purl.uniprot.org/citations/25635767 | http://purl.uniprot.org/core/author | "Hurt A.C."xsd:string |
| http://purl.uniprot.org/citations/25635767 | http://purl.uniprot.org/core/author | "Hurt A.C."xsd:string |
| http://purl.uniprot.org/citations/25635767 | http://purl.uniprot.org/core/author | "Loh T.P."xsd:string |
| http://purl.uniprot.org/citations/25635767 | http://purl.uniprot.org/core/author | "Loh T.P."xsd:string |
| http://purl.uniprot.org/citations/25635767 | http://purl.uniprot.org/core/author | "Loh T.P."xsd:string |
| http://purl.uniprot.org/citations/25635767 | http://purl.uniprot.org/core/author | "Oon L.L."xsd:string |
| http://purl.uniprot.org/citations/25635767 | http://purl.uniprot.org/core/author | "Oon L.L."xsd:string |
| http://purl.uniprot.org/citations/25635767 | http://purl.uniprot.org/core/author | "Oon L.L."xsd:string |
| http://purl.uniprot.org/citations/25635767 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25635767 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |