Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/25636075http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/25636075http://www.w3.org/2000/01/rdf-schema#comment"

Background

Tanshinone IIA (TSN) is one of the main components isolated from Danshen, which is widely used for the treatment of cardiovascular diseases. The transforming growth factor beta (TGF-β) signaling pathway and microRNA (miR)-29b play important roles in the progression of cardiac fibrosis and the modulation of cardiac fibroblast (CF) function. Our study investigated the role of miR-29b in the cardioprotective effects of TSN in postinfarct cardiac remodeling.

Methods and results

Echocardiography demonstrated that medium-dose TSN (TSN-M) and high-dose TSN (TSN-H) significantly inhibited postinfarct cardiac fibrosis and improved the impaired left ventricular function in rats subjected to acute myocardial infarction. Moreover, quantitative real-time polymerase chain reaction and Western blot demonstrated that TSN-M and TSN-H downregulated the expression of TGF-β1, Col1a1, Col3a1, and α-SMA but upregulated the expression of miR-29b. CFs treated with TSN showed inhibited TGF-β signaling pathway, downregulated expression of Col1a1, Col3a1, and α-SMA, and upregulated miR-29b expression in vitro. Furthermore, treatment with a miR-29b inhibitor dramatically inhibited these TSN-induced antifibrotic effects, suggesting that miR-29b may be responsible for the antifibrotic effects of TSN. In addition, treatment with Smad3 siRNA significantly inhibited miR-29b expression in CFs, which implies that Smad3 signaling promotes miR-29b expression on CFs.

Conclusions

TSN exerts antifibrotic effects in postinfarct cardiac fibrosis by upregulating the expression of miR-29b, which is mediated by the TGF-β-Smad3 signaling pathway."xsd:string
http://purl.uniprot.org/citations/25636075http://purl.org/dc/terms/identifier"doi:10.1097/fjc.0000000000000214"xsd:string
http://purl.uniprot.org/citations/25636075http://purl.uniprot.org/core/author"Li H."xsd:string
http://purl.uniprot.org/citations/25636075http://purl.uniprot.org/core/author"Li S."xsd:string
http://purl.uniprot.org/citations/25636075http://purl.uniprot.org/core/author"Li P."xsd:string
http://purl.uniprot.org/citations/25636075http://purl.uniprot.org/core/author"Yang F."xsd:string
http://purl.uniprot.org/citations/25636075http://purl.uniprot.org/core/author"Zhao L."xsd:string
http://purl.uniprot.org/citations/25636075http://purl.uniprot.org/core/author"Shi Q."xsd:string
http://purl.uniprot.org/citations/25636075http://purl.uniprot.org/core/date"2015"xsd:gYear
http://purl.uniprot.org/citations/25636075http://purl.uniprot.org/core/name"J Cardiovasc Pharmacol"xsd:string
http://purl.uniprot.org/citations/25636075http://purl.uniprot.org/core/pages"456-464"xsd:string
http://purl.uniprot.org/citations/25636075http://purl.uniprot.org/core/title"microRNA-29b Mediates the Antifibrotic Effect of Tanshinone IIA in Postinfarct Cardiac Remodeling."xsd:string
http://purl.uniprot.org/citations/25636075http://purl.uniprot.org/core/volume"65"xsd:string
http://purl.uniprot.org/citations/25636075http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/25636075
http://purl.uniprot.org/citations/25636075http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/25636075
http://purl.uniprot.org/uniprot/#_A0A068F650-mappedCitation-25636075http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/25636075
http://purl.uniprot.org/uniprot/#_P13941-mappedCitation-25636075http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/25636075
http://purl.uniprot.org/uniprot/#_A0A8I5ZRN2-mappedCitation-25636075http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/25636075
http://purl.uniprot.org/uniprot/#_A0A8I6G8P4-mappedCitation-25636075http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/25636075
http://purl.uniprot.org/uniprot/#_A0A8I6GG08-mappedCitation-25636075http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/25636075
http://purl.uniprot.org/uniprot/#_P02454-mappedCitation-25636075http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/25636075
http://purl.uniprot.org/uniprot/P13941http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/25636075
http://purl.uniprot.org/uniprot/P02454http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/25636075
http://purl.uniprot.org/uniprot/A0A8I5ZRN2http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/25636075
▶