| http://purl.uniprot.org/citations/25636800 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25636800 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25636800 | http://www.w3.org/2000/01/rdf-schema#comment | "During virus infection, the adaptor proteins MAVS and STING transduce signals from the cytosolic nucleic acid sensors RIG-I and cGAS, respectively, to induce type I interferons (IFNs) and other antiviral molecules. Here we show that MAVS and STING harbor two conserved serine and threonine clusters that are phosphorylated by the kinases IKK and/or TBK1 in response to stimulation. Phosphorylated MAVS and STING then bind to a positively charged surface of interferon regulatory factor 3 (IRF3) and thereby recruit IRF3 for its phosphorylation and activation by TBK1. We further show that TRIF, an adaptor protein in Toll-like receptor signaling, activates IRF3 through a similar phosphorylation-dependent mechanism. These results reveal that phosphorylation of innate adaptor proteins is an essential and conserved mechanism that selectively recruits IRF3 to activate the type I IFN pathway."xsd:string |
| http://purl.uniprot.org/citations/25636800 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.aaa2630"xsd:string |
| http://purl.uniprot.org/citations/25636800 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.aaa2630"xsd:string |
| http://purl.uniprot.org/citations/25636800 | http://purl.uniprot.org/core/author | "Du F."xsd:string |
| http://purl.uniprot.org/citations/25636800 | http://purl.uniprot.org/core/author | "Du F."xsd:string |
| http://purl.uniprot.org/citations/25636800 | http://purl.uniprot.org/core/author | "Cai X."xsd:string |
| http://purl.uniprot.org/citations/25636800 | http://purl.uniprot.org/core/author | "Cai X."xsd:string |
| http://purl.uniprot.org/citations/25636800 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/25636800 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/25636800 | http://purl.uniprot.org/core/author | "Grishin N.V."xsd:string |
| http://purl.uniprot.org/citations/25636800 | http://purl.uniprot.org/core/author | "Grishin N.V."xsd:string |
| http://purl.uniprot.org/citations/25636800 | http://purl.uniprot.org/core/author | "Li T."xsd:string |
| http://purl.uniprot.org/citations/25636800 | http://purl.uniprot.org/core/author | "Li T."xsd:string |
| http://purl.uniprot.org/citations/25636800 | http://purl.uniprot.org/core/author | "Liu S."xsd:string |
| http://purl.uniprot.org/citations/25636800 | http://purl.uniprot.org/core/author | "Liu S."xsd:string |
| http://purl.uniprot.org/citations/25636800 | http://purl.uniprot.org/core/author | "Chen Z.J."xsd:string |
| http://purl.uniprot.org/citations/25636800 | http://purl.uniprot.org/core/author | "Chen Z.J."xsd:string |
| http://purl.uniprot.org/citations/25636800 | http://purl.uniprot.org/core/author | "Ren J."xsd:string |
| http://purl.uniprot.org/citations/25636800 | http://purl.uniprot.org/core/author | "Ren J."xsd:string |
| http://purl.uniprot.org/citations/25636800 | http://purl.uniprot.org/core/author | "Wu J."xsd:string |
| http://purl.uniprot.org/citations/25636800 | http://purl.uniprot.org/core/author | "Wu J."xsd:string |
| http://purl.uniprot.org/citations/25636800 | http://purl.uniprot.org/core/author | "Cong Q."xsd:string |
| http://purl.uniprot.org/citations/25636800 | http://purl.uniprot.org/core/author | "Cong Q."xsd:string |