| http://purl.uniprot.org/citations/25637018 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25637018 | http://www.w3.org/2000/01/rdf-schema#comment | "HIV-1 infection leads to numerous B cell abnormalities, including hypergammaglobulinemia, nonspecific B cell activation, nonspecific class switching, increased cell turnover, breakage of tolerance, increased immature/transitional B cells, B cell malignancies, as well as a loss of capacity to generate and maintain memory, all of which contribute to a global impairment of the immune humoral compartment. Several cytokines and soluble factors, which are increased in sera of HIV-1-infected individuals, have been suggested to directly or indirectly contribute to these B cell dysfunctions, and one of these is the B cell-activating factor (BAFF). We report in this study that HIV-1 (X4- and R5-tropic) upregulates BAFF expression and secretion by human monocytes. Moreover, we show that the virus-mediated production of BAFF by monocytes relies on a type I IFN response by a small percentage of plasmacytoid dendritic cells (pDCs) present in the monocyte cultures. HIV-1-induced type I IFN by pDCs triggers BAFF production in both classical and intermediate monocytes, but not in nonclassical monocytes, which nonetheless display a very strong basal BAFF production. We report also that basal BAFF secretion was higher in monocytes obtained from females compared with those from male donors. This study provides a novel mechanistic explanation for the increased BAFF levels observed during HIV-1 infection and highlights the importance of pDC/monocyte crosstalk to drive BAFF secretion."xsd:string |
| http://purl.uniprot.org/citations/25637018 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1402147"xsd:string |
| http://purl.uniprot.org/citations/25637018 | http://purl.uniprot.org/core/author | "Gomez A.M."xsd:string |
| http://purl.uniprot.org/citations/25637018 | http://purl.uniprot.org/core/author | "Ouellet M."xsd:string |
| http://purl.uniprot.org/citations/25637018 | http://purl.uniprot.org/core/author | "Tremblay M.J."xsd:string |
| http://purl.uniprot.org/citations/25637018 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25637018 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/25637018 | http://purl.uniprot.org/core/pages | "2300-2308"xsd:string |
| http://purl.uniprot.org/citations/25637018 | http://purl.uniprot.org/core/title | "HIV-1-triggered release of type I IFN by plasmacytoid dendritic cells induces BAFF production in monocytes."xsd:string |
| http://purl.uniprot.org/citations/25637018 | http://purl.uniprot.org/core/volume | "194"xsd:string |
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