| http://purl.uniprot.org/citations/25637053 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25637053 | http://www.w3.org/2000/01/rdf-schema#comment | "Transferrin receptor-2 is a transmembrane protein whose expression is restricted to hepatocytes and erythroid cells. Transferrin receptor-2 has a regulatory function in iron homeostasis, since its inactivation causes systemic iron overload. Hepatic transferrin receptor-2 participates in iron sensing and is involved in hepcidin activation, although the mechanism remains unclear. Erythroid transferrin receptor-2 associates with and stabilizes erythropoietin receptors on the erythroblast surface and is essential to control erythrocyte production in iron deficiency. We identified a soluble form of transferrin receptor-2 in the media of transfected cells and showed that cultured human erythroid cells release an endogenous soluble form. Soluble transferrin receptor-2 originates from a cleavage of the cell surface protein, which is inhibited by diferric transferrin in a dose-dependent manner. Accordingly, the shedding of the transferrin receptor-2 variant G679A, mutated in the Arginine-Glycine-Aspartic acid motif and unable to bind diferric transferrin, is not modulated by the ligand. This observation links the process of transferrin receptor-2 removal from the plasma membrane to iron homeostasis. Soluble transferrin receptor-2 does not affect the binding of erythropoietin to erythropoietin receptor or the consequent signaling and partially inhibits hepcidin promoter activation only in vitro. Whether it is a component of the signals released by erythropoiesis in iron deficiency remains to be investigated. Our results indicate that membrane transferrin receptor-2, a sensor of circulating iron, is released from the cell membrane in iron deficiency."xsd:string |
| http://purl.uniprot.org/citations/25637053 | http://purl.org/dc/terms/identifier | "doi:10.3324/haematol.2014.118521"xsd:string |
| http://purl.uniprot.org/citations/25637053 | http://purl.uniprot.org/core/author | "Silvestri L."xsd:string |
| http://purl.uniprot.org/citations/25637053 | http://purl.uniprot.org/core/author | "Lacombe C."xsd:string |
| http://purl.uniprot.org/citations/25637053 | http://purl.uniprot.org/core/author | "Pagani A."xsd:string |
| http://purl.uniprot.org/citations/25637053 | http://purl.uniprot.org/core/author | "Mayeux P."xsd:string |
| http://purl.uniprot.org/citations/25637053 | http://purl.uniprot.org/core/author | "Verdier F."xsd:string |
| http://purl.uniprot.org/citations/25637053 | http://purl.uniprot.org/core/author | "Camaschella C."xsd:string |
| http://purl.uniprot.org/citations/25637053 | http://purl.uniprot.org/core/author | "Nai A."xsd:string |
| http://purl.uniprot.org/citations/25637053 | http://purl.uniprot.org/core/author | "Rausa M."xsd:string |
| http://purl.uniprot.org/citations/25637053 | http://purl.uniprot.org/core/author | "Vieillevoye M."xsd:string |
| http://purl.uniprot.org/citations/25637053 | http://purl.uniprot.org/core/author | "Ladli M."xsd:string |
| http://purl.uniprot.org/citations/25637053 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25637053 | http://purl.uniprot.org/core/name | "Haematologica"xsd:string |
| http://purl.uniprot.org/citations/25637053 | http://purl.uniprot.org/core/pages | "458-465"xsd:string |
| http://purl.uniprot.org/citations/25637053 | http://purl.uniprot.org/core/title | "Regulation of cell surface transferrin receptor-2 by iron-dependent cleavage and release of a soluble form."xsd:string |
| http://purl.uniprot.org/citations/25637053 | http://purl.uniprot.org/core/volume | "100"xsd:string |
| http://purl.uniprot.org/citations/25637053 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25637053 |
| http://purl.uniprot.org/citations/25637053 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25637053 |
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| http://purl.uniprot.org/uniprot/#_Q9UP52-mappedCitation-25637053 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25637053 |
| http://purl.uniprot.org/uniprot/A7E248 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25637053 |
| http://purl.uniprot.org/uniprot/Q9UP52 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25637053 |