| http://purl.uniprot.org/citations/25640077 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25640077 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25640077 | http://www.w3.org/2000/01/rdf-schema#comment | "TRPA1 and TRPV1 are crucial pain mediators, but how their interaction contributes to persistent pain is unknown. Here, we identify Tmem100 as a potentiating modulator of TRPA1-V1 complexes. Tmem100 is coexpressed and forms a complex with TRPA1 and TRPV1 in DRG neurons. Tmem100-deficient mice show a reduction in inflammatory mechanical hyperalgesia and TRPA1-but not TRPV1-mediated pain. Single-channel recording in a heterologous system reveals that Tmem100 selectively potentiates TRPA1 activity in a TRPV1-dependent manner. Mechanistically, Tmem100 weakens the association of TRPA1 and TRPV1, thereby releasing the inhibition of TRPA1 by TRPV1. A Tmem100 mutant, Tmem100-3Q, exerts the opposite effect; i.e., it enhances the association of TRPA1 and TRPV1 and strongly inhibits TRPA1. Strikingly, a cell-permeable peptide (CPP) containing the C-terminal sequence of Tmem100-3Q mimics its effect and inhibits persistent pain. Our study unveils a context-dependent modulation of the TRPA1-V1 complex, and Tmem100-3Q CPP is a promising pain therapy."xsd:string |
| http://purl.uniprot.org/citations/25640077 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2014.12.065"xsd:string |
| http://purl.uniprot.org/citations/25640077 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2014.12.065"xsd:string |
| http://purl.uniprot.org/citations/25640077 | http://purl.uniprot.org/core/author | "Dong X."xsd:string |
| http://purl.uniprot.org/citations/25640077 | http://purl.uniprot.org/core/author | "Dong X."xsd:string |
| http://purl.uniprot.org/citations/25640077 | http://purl.uniprot.org/core/author | "Guan Y."xsd:string |
| http://purl.uniprot.org/citations/25640077 | http://purl.uniprot.org/core/author | "Guan Y."xsd:string |
| http://purl.uniprot.org/citations/25640077 | http://purl.uniprot.org/core/author | "Geng Y."xsd:string |
| http://purl.uniprot.org/citations/25640077 | http://purl.uniprot.org/core/author | "Geng Y."xsd:string |
| http://purl.uniprot.org/citations/25640077 | http://purl.uniprot.org/core/author | "Tang Z."xsd:string |
| http://purl.uniprot.org/citations/25640077 | http://purl.uniprot.org/core/author | "Tang Z."xsd:string |
| http://purl.uniprot.org/citations/25640077 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/25640077 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/25640077 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/25640077 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/25640077 | http://purl.uniprot.org/core/author | "Zou W."xsd:string |
| http://purl.uniprot.org/citations/25640077 | http://purl.uniprot.org/core/author | "Zou W."xsd:string |
| http://purl.uniprot.org/citations/25640077 | http://purl.uniprot.org/core/author | "Zheng Q."xsd:string |
| http://purl.uniprot.org/citations/25640077 | http://purl.uniprot.org/core/author | "Zheng Q."xsd:string |
| http://purl.uniprot.org/citations/25640077 | http://purl.uniprot.org/core/author | "Akopian A.N."xsd:string |
| http://purl.uniprot.org/citations/25640077 | http://purl.uniprot.org/core/author | "Akopian A.N."xsd:string |
| http://purl.uniprot.org/citations/25640077 | http://purl.uniprot.org/core/author | "Tiwari V."xsd:string |
| http://purl.uniprot.org/citations/25640077 | http://purl.uniprot.org/core/author | "Tiwari V."xsd:string |