| http://purl.uniprot.org/citations/25640113 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25640113 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25640113 | http://www.w3.org/2000/01/rdf-schema#comment | "Endoparasitoids develop inside another insect by regulating host immunity and development via maternal factors injected into hosts during oviposition. Prior results have provided insights into parasitism-induced immunosuppression, including the neuropeptide accumulation in parasitized insects. Nonetheless, our understanding of neuropeptide influence on host development and behavior is not yet complete. We posed the hypothesis that parasitization alters expression of genes encoding pro-neuropeptides and used larvae of Plutella xylostella and its endoparasitoid, Cotesia vestalis to test our hypothesis. We prepared transcriptomes from the larval P. xylostella brain-CC-CA complex and identified transcripts encoding 19 neuropeptides. All corresponding cDNAs were confirmed by RACE. Our results demonstrate that parasitism significantly down-regulated, or delayed, expression of genes encoding pro-neuropeptides within 48 h post-parasitization. Changing expression of these genes may account for the previously reported decreased feeding behavior, reduced growth rates and aborted development in the host larvae. In effect, parasitization may operate at the molecular level within the CNS to create global changes in larval host biology. The significance of our finding is that, in addition to the known effects on immunity, parasitoids influence host pro-neuropeptide gene transcription. This finding reveals a new mechanism operating in host-parasitoid relationships to the advantage of the parasitoid."xsd:string |
| http://purl.uniprot.org/citations/25640113 | http://purl.org/dc/terms/identifier | "doi:10.1038/srep08173"xsd:string |
| http://purl.uniprot.org/citations/25640113 | http://purl.org/dc/terms/identifier | "doi:10.1038/srep08173"xsd:string |
| http://purl.uniprot.org/citations/25640113 | http://purl.uniprot.org/core/author | "Dong S."xsd:string |
| http://purl.uniprot.org/citations/25640113 | http://purl.uniprot.org/core/author | "Dong S."xsd:string |
| http://purl.uniprot.org/citations/25640113 | http://purl.uniprot.org/core/author | "Shi M."xsd:string |
| http://purl.uniprot.org/citations/25640113 | http://purl.uniprot.org/core/author | "Shi M."xsd:string |
| http://purl.uniprot.org/citations/25640113 | http://purl.uniprot.org/core/author | "Yang Y.Y."xsd:string |
| http://purl.uniprot.org/citations/25640113 | http://purl.uniprot.org/core/author | "Yang Y.Y."xsd:string |
| http://purl.uniprot.org/citations/25640113 | http://purl.uniprot.org/core/author | "Li M.T."xsd:string |
| http://purl.uniprot.org/citations/25640113 | http://purl.uniprot.org/core/author | "Li M.T."xsd:string |
| http://purl.uniprot.org/citations/25640113 | http://purl.uniprot.org/core/author | "Stanley D."xsd:string |
| http://purl.uniprot.org/citations/25640113 | http://purl.uniprot.org/core/author | "Stanley D."xsd:string |
| http://purl.uniprot.org/citations/25640113 | http://purl.uniprot.org/core/author | "Chen X.X."xsd:string |
| http://purl.uniprot.org/citations/25640113 | http://purl.uniprot.org/core/author | "Chen X.X."xsd:string |
| http://purl.uniprot.org/citations/25640113 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25640113 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25640113 | http://purl.uniprot.org/core/name | "Sci. Rep."xsd:string |
| http://purl.uniprot.org/citations/25640113 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/25640113 | http://purl.uniprot.org/core/pages | "8173"xsd:string |
| http://purl.uniprot.org/citations/25640113 | http://purl.uniprot.org/core/pages | "8173"xsd:string |
| http://purl.uniprot.org/citations/25640113 | http://purl.uniprot.org/core/title | "The Endoparasitoid, Cotesia vestalis, Regulates Host Physiology by Reprogramming the Neuropeptide Transcriptional Network."xsd:string |
| http://purl.uniprot.org/citations/25640113 | http://purl.uniprot.org/core/title | "The endoparasitoid, Cotesia vestalis, regulates host physiology by reprogramming the neuropeptide transcriptional network."xsd:string |