| http://purl.uniprot.org/citations/25641411 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25641411 | http://www.w3.org/2000/01/rdf-schema#comment | "Scavenger receptor associated with endothelial cells (SREC-I) was previously shown to be expressed by immune cells and to play a role in CD8(+)-mediated T cell immunity. SREC-I was also shown to modulate the function of Toll like receptors with essential roles in innate immunity. Here we have shown that SREC-I enhanced double stranded RNA (dsRNA)-mediated Toll like receptor-3 (TLR3) activation. Viral double stranded RNA (dsRNA) was demonstrated to be a pathogen associated molecular pattern (PAMP) signaling viral infection. We found that in human monocyte/macrophage THP1 cells as well as murine bone marrow derived macrophages SREC-I led to elevated responses to the dsRNA-like molecule polyinosine-polycytidylic acid (Poly I:C) and enhanced production of inflammatory cytokines. Our data also showed that intracellular/endocytic TLR3 could directly interact with SREC-I in the presence of Poly I:C. The internalized ligand, along with TLR3 and SREC-I localized in endosomes within macrophages and in HEK293 cells engineered to express TLR3 and SREC-I. SREC-I also stimulated dsRNA-mediated TLR3 activation of signaling through the NFκβ, MAP kinase and interferon regulatory factor 3 (IRF3) pathways leading to expression of cytokines, most notably interleukin-8 and interferon-β. We therefore hypothesized that SREC-I could be a receptor capable of internalizing Poly I:C, boosting TLR3 mediated inflammatory signaling and stimulating cytokine production in macrophages."xsd:string |
| http://purl.uniprot.org/citations/25641411 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.imbio.2014.12.011"xsd:string |
| http://purl.uniprot.org/citations/25641411 | http://purl.uniprot.org/core/author | "Calderwood S.K."xsd:string |
| http://purl.uniprot.org/citations/25641411 | http://purl.uniprot.org/core/author | "Ahmad R."xsd:string |
| http://purl.uniprot.org/citations/25641411 | http://purl.uniprot.org/core/author | "Gong J."xsd:string |
| http://purl.uniprot.org/citations/25641411 | http://purl.uniprot.org/core/author | "Murshid A."xsd:string |
| http://purl.uniprot.org/citations/25641411 | http://purl.uniprot.org/core/author | "Borges T.J."xsd:string |
| http://purl.uniprot.org/citations/25641411 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25641411 | http://purl.uniprot.org/core/name | "Immunobiology"xsd:string |
| http://purl.uniprot.org/citations/25641411 | http://purl.uniprot.org/core/pages | "823-832"xsd:string |
| http://purl.uniprot.org/citations/25641411 | http://purl.uniprot.org/core/title | "Scavenger receptor SREC-I promotes double stranded RNA-mediated TLR3 activation in human monocytes."xsd:string |
| http://purl.uniprot.org/citations/25641411 | http://purl.uniprot.org/core/volume | "220"xsd:string |
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