| http://purl.uniprot.org/citations/25644384 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25644384 | http://www.w3.org/2000/01/rdf-schema#comment | "General cognitive function is substantially heritable across the human life course from adolescence to old age. We investigated the genetic contribution to variation in this important, health- and well-being-related trait in middle-aged and older adults. We conducted a meta-analysis of genome-wide association studies of 31 cohorts (N=53,949) in which the participants had undertaken multiple, diverse cognitive tests. A general cognitive function phenotype was tested for, and created in each cohort by principal component analysis. We report 13 genome-wide significant single-nucleotide polymorphism (SNP) associations in three genomic regions, 6q16.1, 14q12 and 19q13.32 (best SNP and closest gene, respectively: rs10457441, P=3.93 × 10(-9), MIR2113; rs17522122, P=2.55 × 10(-8), AKAP6; rs10119, P=5.67 × 10(-9), APOE/TOMM40). We report one gene-based significant association with the HMGN1 gene located on chromosome 21 (P=1 × 10(-6)). These genes have previously been associated with neuropsychiatric phenotypes. Meta-analysis results are consistent with a polygenic model of inheritance. To estimate SNP-based heritability, the genome-wide complex trait analysis procedure was applied to two large cohorts, the Atherosclerosis Risk in Communities Study (N=6617) and the Health and Retirement Study (N=5976). The proportion of phenotypic variation accounted for by all genotyped common SNPs was 29% (s.e.=5%) and 28% (s.e.=7%), respectively. Using polygenic prediction analysis, ~1.2% of the variance in general cognitive function was predicted in the Generation Scotland cohort (N=5487; P=1.5 × 10(-17)). In hypothesis-driven tests, there was significant association between general cognitive function and four genes previously associated with Alzheimer's disease: TOMM40, APOE, ABCG1 and MEF2C."xsd:string |
| http://purl.uniprot.org/citations/25644384 | http://purl.org/dc/terms/identifier | "doi:10.1038/mp.2014.188"xsd:string |
| http://purl.uniprot.org/citations/25644384 | http://purl.uniprot.org/core/author | "Liu T."xsd:string |
| http://purl.uniprot.org/citations/25644384 | http://purl.uniprot.org/core/author | "Li G."xsd:string |
| http://purl.uniprot.org/citations/25644384 | http://purl.uniprot.org/core/author | "Schmidt R."xsd:string |
| http://purl.uniprot.org/citations/25644384 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/25644384 | http://purl.uniprot.org/core/author | "Yang Q."xsd:string |
| http://purl.uniprot.org/citations/25644384 | http://purl.uniprot.org/core/author | "Yu L."xsd:string |
| http://purl.uniprot.org/citations/25644384 | http://purl.uniprot.org/core/author | "Zhao W."xsd:string |
| http://purl.uniprot.org/citations/25644384 | http://purl.uniprot.org/core/author | "Schmidt H."xsd:string |
| http://purl.uniprot.org/citations/25644384 | http://purl.uniprot.org/core/author | "Steen V.M."xsd:string |
| http://purl.uniprot.org/citations/25644384 | http://purl.uniprot.org/core/author | "Knopman D.S."xsd:string |
| http://purl.uniprot.org/citations/25644384 | http://purl.uniprot.org/core/author | "Rotter J.I."xsd:string |
| http://purl.uniprot.org/citations/25644384 | http://purl.uniprot.org/core/author | "Taylor K.D."xsd:string |
| http://purl.uniprot.org/citations/25644384 | http://purl.uniprot.org/core/author | "Ames D."xsd:string |
| http://purl.uniprot.org/citations/25644384 | http://purl.uniprot.org/core/author | "Hofman A."xsd:string |
| http://purl.uniprot.org/citations/25644384 | http://purl.uniprot.org/core/author | "Schofield P.R."xsd:string |
| http://purl.uniprot.org/citations/25644384 | http://purl.uniprot.org/core/author | "Lopez O.L."xsd:string |
| http://purl.uniprot.org/citations/25644384 | http://purl.uniprot.org/core/author | "Jukema J.W."xsd:string |
| http://purl.uniprot.org/citations/25644384 | http://purl.uniprot.org/core/author | "Palotie A."xsd:string |
| http://purl.uniprot.org/citations/25644384 | http://purl.uniprot.org/core/author | "Smith J.A."xsd:string |
| http://purl.uniprot.org/citations/25644384 | http://purl.uniprot.org/core/author | "Lee T."xsd:string |
| http://purl.uniprot.org/citations/25644384 | http://purl.uniprot.org/core/author | "Amin N."xsd:string |
| http://purl.uniprot.org/citations/25644384 | http://purl.uniprot.org/core/author | "Campbell H."xsd:string |