| http://purl.uniprot.org/citations/25645248 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25645248 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectiveChronic excessive food intake leads to energy imbalance, resulting in hepatic steatosis and inflammation. Interleukin-32 (IL-32) is known to be a pro-inflammatory cytokine associated with chronic inflammation and cancer. Therefore, the relationship between IL-32 and chronic excessive food intake-induced liver disease was investigated.MethodsMale IL-32β transgenic and wild-type mice were fed a high-fat diet (HFD) for 15 weeks. They were compared with wild-type mice on a standard chow diet. Daily food intake, body and liver weight, serum biochemistry, histopathological analysis of the liver, and hepatic immune response were determined.ResultsIL-32β mice on HFD showed lower lipid accumulation, reduced infiltration of immune cells, and lower production of pro-inflammatory cytokines in the liver. The expression of the peroxisome proliferator-activated receptor γ (PPARγ) was downregulated and the adenosine 50-monophosphate (AMP)-activated protein kinase (AMPK) was activated in the liver of IL-32β mice compared to wild-type mice. Furthermore, IL-32β over-expression activated the AMPK pathway and IL-32β downregulation inactivated the AMPK pathway in HepG2 cells under high-glucose conditions.ConclusionsThese data suggest that IL-32β modulates lipid accumulation through inhibition of PPARγ expression and AMPK activation."xsd:string |
| http://purl.uniprot.org/citations/25645248 | http://purl.org/dc/terms/identifier | "doi:10.1002/oby.21001"xsd:string |
| http://purl.uniprot.org/citations/25645248 | http://purl.uniprot.org/core/author | "Lee D.H."xsd:string |
| http://purl.uniprot.org/citations/25645248 | http://purl.uniprot.org/core/author | "Park J.H."xsd:string |
| http://purl.uniprot.org/citations/25645248 | http://purl.uniprot.org/core/author | "Song M.J."xsd:string |
| http://purl.uniprot.org/citations/25645248 | http://purl.uniprot.org/core/author | "Hong J.T."xsd:string |
| http://purl.uniprot.org/citations/25645248 | http://purl.uniprot.org/core/author | "Yoon D.Y."xsd:string |
| http://purl.uniprot.org/citations/25645248 | http://purl.uniprot.org/core/author | "Han S.B."xsd:string |
| http://purl.uniprot.org/citations/25645248 | http://purl.uniprot.org/core/author | "Hong J.E."xsd:string |
| http://purl.uniprot.org/citations/25645248 | http://purl.uniprot.org/core/author | "Yun H.M."xsd:string |
| http://purl.uniprot.org/citations/25645248 | http://purl.uniprot.org/core/author | "Hwang C.J."xsd:string |
| http://purl.uniprot.org/citations/25645248 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25645248 | http://purl.uniprot.org/core/name | "Obesity (Silver Spring)"xsd:string |
| http://purl.uniprot.org/citations/25645248 | http://purl.uniprot.org/core/pages | "615-622"xsd:string |
| http://purl.uniprot.org/citations/25645248 | http://purl.uniprot.org/core/title | "Interleukin-32beta ameliorates metabolic disorder and liver damage in mice fed high-fat diet."xsd:string |
| http://purl.uniprot.org/citations/25645248 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/25645248 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25645248 |
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| http://purl.uniprot.org/uniprot/#_C6GKH1-mappedCitation-25645248 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25645248 |
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| http://purl.uniprot.org/uniprot/#_G3LU47-mappedCitation-25645248 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25645248 |
| http://purl.uniprot.org/uniprot/#_P24001-mappedCitation-25645248 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25645248 |
| http://purl.uniprot.org/uniprot/C6GKH2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25645248 |
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