| http://purl.uniprot.org/citations/25645944 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25645944 | http://www.w3.org/2000/01/rdf-schema#comment | "The indifferent mammalian embryonic gonad generates an ovary or testis, but the factors involved are still poorly known. The Wnt-4 signal represents one critical female determinant, since its absence leads to partial female-to-male sex reversal in mouse, but its signalling is as well implicated in the testis development. We used the Wnt-4 deficient mouse as a model to identify candidate gonadogenesis genes, and found that the Notum, Phlda2, Runx-1 and Msx1 genes are typical of the wild-type ovary and the Osr2, Dach2, Pitx2 and Tacr3 genes of the testis. Strikingly, the expression of these latter genes becomes reversed in the Wnt-4 knock-out ovary, suggesting a role in ovarian development. We identified the transcription factor Runx-1 as a Wnt-4 signalling target gene, since it is expressed in the ovary and is reduced upon Wnt-4 knock-out. Consistent with this, introduction of the Wnt-4 signal into early ovary cells ex vivo induces Runx-1 expression, while conversely Wnt-4 expression is down-regulated in the absence of Runx-1. We conclude that the Runx-1 gene can be a Wnt-4 signalling target, and that Runx-1 and Wnt-4 are mutually interdependent in their expression. The changes in gene expression due to the absence of Wnt-4 in gonads reflect the sexually dimorphic role of this signal and its complex gene network in mammalian gonad development."xsd:string |
| http://purl.uniprot.org/citations/25645944 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yexcr.2015.01.010"xsd:string |
| http://purl.uniprot.org/citations/25645944 | http://purl.uniprot.org/core/author | "Sun Z."xsd:string |
| http://purl.uniprot.org/citations/25645944 | http://purl.uniprot.org/core/author | "Shen B."xsd:string |
| http://purl.uniprot.org/citations/25645944 | http://purl.uniprot.org/core/author | "Xu Q."xsd:string |
| http://purl.uniprot.org/citations/25645944 | http://purl.uniprot.org/core/author | "Yan W."xsd:string |
| http://purl.uniprot.org/citations/25645944 | http://purl.uniprot.org/core/author | "Quaggin S."xsd:string |
| http://purl.uniprot.org/citations/25645944 | http://purl.uniprot.org/core/author | "Vainio S.J."xsd:string |
| http://purl.uniprot.org/citations/25645944 | http://purl.uniprot.org/core/author | "Karjalainen R."xsd:string |
| http://purl.uniprot.org/citations/25645944 | http://purl.uniprot.org/core/author | "Samoylenko A."xsd:string |
| http://purl.uniprot.org/citations/25645944 | http://purl.uniprot.org/core/author | "Naillat F."xsd:string |
| http://purl.uniprot.org/citations/25645944 | http://purl.uniprot.org/core/author | "Liakhovitskaia A."xsd:string |
| http://purl.uniprot.org/citations/25645944 | http://purl.uniprot.org/core/author | "Medvinsky A."xsd:string |
| http://purl.uniprot.org/citations/25645944 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25645944 | http://purl.uniprot.org/core/name | "Exp Cell Res"xsd:string |
| http://purl.uniprot.org/citations/25645944 | http://purl.uniprot.org/core/pages | "163-178"xsd:string |
| http://purl.uniprot.org/citations/25645944 | http://purl.uniprot.org/core/title | "Identification of the genes regulated by Wnt-4, a critical signal for commitment of the ovary."xsd:string |
| http://purl.uniprot.org/citations/25645944 | http://purl.uniprot.org/core/volume | "332"xsd:string |
| http://purl.uniprot.org/citations/25645944 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25645944 |
| http://purl.uniprot.org/citations/25645944 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25645944 |
| http://purl.uniprot.org/uniprot/#_A0A087WPL0-mappedCitation-25645944 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25645944 |
| http://purl.uniprot.org/uniprot/#_A0A286YDK1-mappedCitation-25645944 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25645944 |
| http://purl.uniprot.org/uniprot/#_A0A087WR05-mappedCitation-25645944 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25645944 |
| http://purl.uniprot.org/uniprot/#_A0A140LIM7-mappedCitation-25645944 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25645944 |