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| http://purl.uniprot.org/citations/25646409 | http://www.w3.org/2000/01/rdf-schema#comment | "Synaptonemal complexes (SCs) are meiosis-specific multiprotein complexes that are essential for synapsis, recombination, and segregation of homologous chromosomes, but the molecular organization of SCs remains unclear. We used immunofluorescence labeling in combination with super-resolution imaging and average position determination to investigate the molecular architecture of SCs. Combination of 2D super-resolution images recorded from different areas of the helical ladder-like structure allowed us to reconstruct the 3D molecular organization of the mammalian SC with isotropic resolution. The central element is composed of two parallel cables at a distance of ∼ 100 nm, which are oriented perpendicular to two parallel cables of the lateral element arranged at a distance of ∼ 220 nm. The two parallel cable elements form twisted helical structures that are connected by transversal filaments by their N and C termini. A single-cell preparation generates sufficient localizations to compile a 3D model of the SC with nanometer precision."xsd:string |
| http://purl.uniprot.org/citations/25646409 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1414814112"xsd:string |
| http://purl.uniprot.org/citations/25646409 | http://purl.uniprot.org/core/author | "Sauer M."xsd:string |
| http://purl.uniprot.org/citations/25646409 | http://purl.uniprot.org/core/author | "Franke C."xsd:string |
| http://purl.uniprot.org/citations/25646409 | http://purl.uniprot.org/core/author | "Holm T."xsd:string |
| http://purl.uniprot.org/citations/25646409 | http://purl.uniprot.org/core/author | "Benavente R."xsd:string |
| http://purl.uniprot.org/citations/25646409 | http://purl.uniprot.org/core/author | "Schucker K."xsd:string |
| http://purl.uniprot.org/citations/25646409 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25646409 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/25646409 | http://purl.uniprot.org/core/pages | "2029-2033"xsd:string |
| http://purl.uniprot.org/citations/25646409 | http://purl.uniprot.org/core/title | "Elucidation of synaptonemal complex organization by super-resolution imaging with isotropic resolution."xsd:string |
| http://purl.uniprot.org/citations/25646409 | http://purl.uniprot.org/core/volume | "112"xsd:string |
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