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| http://purl.uniprot.org/citations/25646416 | http://www.w3.org/2000/01/rdf-schema#comment | "Vaccines eliciting immunity against influenza A viruses (IAVs) are currently antibody-based with hemagglutinin-directed antibody titer the only universally accepted immune correlate of protection. To investigate the disconnection between observed CD8 T-cell responses and immunity to IAV, we used a Poisson liquid chromatography data-independent acquisition MS method to physically detect PR8/34 (H1N1), X31 (H3N2), and Victoria/75 (H3N2) epitopes bound to HLA-A*02:01 on human epithelial cells following in vitro infection. Among 32 PR8 peptides (8-10mers) with predicted IC50 < 60 nM, 9 were present, whereas 23 were absent. At 18 h postinfection, epitope copies per cell varied from a low of 0.5 for M13-11 to a high of >500 for M1(58-66) with PA, HA, PB1, PB2, and NA epitopes also detected. However, aside from M1(58-66), natural CD8 memory responses against conserved presented epitopes were either absent or only weakly observed by blood Elispot. Moreover, the functional avidities of the immunodominant M1(58-66)/HLA-A*02:01-specific T cells were so poor as to be unable to effectively recognize infected human epithelium. Analysis of T-cell responses to primary PR8 infection in HLA-A*02:01 transgenic B6 mice underscores the poor avidity of T cells recognizing M1(58-66). By maintaining high levels of surface expression of this epitope on epithelial and dendritic cells, the virus exploits the combination of immunodominance and functional inadequacy to evade HLA-A*02:01-restricted T-cell immunity. A rational approach to CD8 vaccines must characterize processing and presentation of pathogen-derived epitopes as well as resultant immune responses. Correspondingly, vaccines may be directed against "stealth" epitopes, overriding viral chicanery."xsd:string |
| http://purl.uniprot.org/citations/25646416 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1423482112"xsd:string |
| http://purl.uniprot.org/citations/25646416 | http://purl.uniprot.org/core/author | "Reinhold B.B."xsd:string |
| http://purl.uniprot.org/citations/25646416 | http://purl.uniprot.org/core/author | "Reinherz E.L."xsd:string |
| http://purl.uniprot.org/citations/25646416 | http://purl.uniprot.org/core/author | "Ivanov A.R."xsd:string |
| http://purl.uniprot.org/citations/25646416 | http://purl.uniprot.org/core/author | "Karger B.L."xsd:string |
| http://purl.uniprot.org/citations/25646416 | http://purl.uniprot.org/core/author | "Keskin D.B."xsd:string |
| http://purl.uniprot.org/citations/25646416 | http://purl.uniprot.org/core/author | "Zhang G.L."xsd:string |
| http://purl.uniprot.org/citations/25646416 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25646416 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/25646416 | http://purl.uniprot.org/core/pages | "2151-2156"xsd:string |
| http://purl.uniprot.org/citations/25646416 | http://purl.uniprot.org/core/title | "Physical detection of influenza A epitopes identifies a stealth subset on human lung epithelium evading natural CD8 immunity."xsd:string |
| http://purl.uniprot.org/citations/25646416 | http://purl.uniprot.org/core/volume | "112"xsd:string |
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