| http://purl.uniprot.org/citations/25650755 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25650755 | http://www.w3.org/2000/01/rdf-schema#comment | "The genetic and molecular mechanisms that initiate and maintain pituitary tumorigenesis are poorly understood. Nonfunctioning tumors of the gonadotrope lineage represent 35% of all tumors; are usually macroadenomas, often resulting in hypopituitarism; and have no medical treatments. Using expression microarrays combined with whole-genome copy number screens on individual human tumors, we identified the mammalian sterile-20-like kinase (MST4) transcript, which was amplified within chromosome Xq26.2 in one tumor and up-regulated in all gonadotrope tumor samples. MST4 mRNA and protein were consistently overexpressed in human tumors compared with normal pituitaries. To mimic the pituitary tumor microenvironment, a hypoxia model using LβT2 murine gonadotrope cells was created to examine the functional role of the kinase. During long-term hypoxia, MST4 expression increased colony formation in a soft agar assay and rates of cell proliferation by activating p38 MAPK and AKT. Under short-term severe hypoxic stress, MST4 decreased the rates of apoptosis via p38 MAPK, AKT, hypoxia-inducible factor-1, and its cell-specific downstream targets. Analysis of MST4 mutants confirmed the importance of the kinase sequence but not the regulatory C terminus for its functional effects. Together these data identify the MST4 kinase as a novel candidate to mediate human pituitary tumorigenesis in a hypoxic environment and position it as a potential therapeutic target."xsd:string |
| http://purl.uniprot.org/citations/25650755 | http://purl.org/dc/terms/identifier | "doi:10.1210/me.2014-1332"xsd:string |
| http://purl.uniprot.org/citations/25650755 | http://purl.uniprot.org/core/author | "Xu M."xsd:string |
| http://purl.uniprot.org/citations/25650755 | http://purl.uniprot.org/core/author | "Xiong W."xsd:string |
| http://purl.uniprot.org/citations/25650755 | http://purl.uniprot.org/core/author | "Colgan S.P."xsd:string |
| http://purl.uniprot.org/citations/25650755 | http://purl.uniprot.org/core/author | "Kleinschmidt-Demasters B.K."xsd:string |
| http://purl.uniprot.org/citations/25650755 | http://purl.uniprot.org/core/author | "Wierman M.E."xsd:string |
| http://purl.uniprot.org/citations/25650755 | http://purl.uniprot.org/core/author | "Brodsky K.S."xsd:string |
| http://purl.uniprot.org/citations/25650755 | http://purl.uniprot.org/core/author | "Knox A.J."xsd:string |
| http://purl.uniprot.org/citations/25650755 | http://purl.uniprot.org/core/author | "Kiseljak-Vassiliades K."xsd:string |
| http://purl.uniprot.org/citations/25650755 | http://purl.uniprot.org/core/author | "Lillehei K.O."xsd:string |
| http://purl.uniprot.org/citations/25650755 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25650755 | http://purl.uniprot.org/core/name | "Mol Endocrinol"xsd:string |
| http://purl.uniprot.org/citations/25650755 | http://purl.uniprot.org/core/pages | "460-472"xsd:string |
| http://purl.uniprot.org/citations/25650755 | http://purl.uniprot.org/core/title | "Mammalian Ste20-like kinase 4 promotes pituitary cell proliferation and survival under hypoxia."xsd:string |
| http://purl.uniprot.org/citations/25650755 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/25650755 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25650755 |
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| http://purl.uniprot.org/uniprot/#_Q9NWX4-mappedCitation-25650755 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25650755 |