| http://purl.uniprot.org/citations/25651184 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25651184 | http://www.w3.org/2000/01/rdf-schema#comment | "Decretins, hormones induced by fasting that suppress insulin production and secretion, have been postulated from classical human metabolic studies. From genetic screens, we identified Drosophila Limostatin (Lst), a peptide hormone that suppresses insulin secretion. Lst is induced by nutrient restriction in gut-associated endocrine cells. limostatin deficiency led to hyperinsulinemia, hypoglycemia, and excess adiposity. A conserved 15-residue polypeptide encoded by limostatin suppressed secretion by insulin-producing cells. Targeted knockdown of CG9918, a Drosophila ortholog of Neuromedin U receptors (NMURs), in insulin-producing cells phenocopied limostatin deficiency and attenuated insulin suppression by purified Lst, suggesting CG9918 encodes an Lst receptor. NMUR1 is expressed in islet β cells, and purified NMU suppresses insulin secretion from human islets. A human mutant NMU variant that co-segregates with familial early-onset obesity and hyperinsulinemia fails to suppress insulin secretion. We propose Lst as an index member of an ancient hormone class called decretins, which suppress insulin output."xsd:string |
| http://purl.uniprot.org/citations/25651184 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cmet.2015.01.006"xsd:string |
| http://purl.uniprot.org/citations/25651184 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/25651184 | http://purl.uniprot.org/core/author | "Kim S.K."xsd:string |
| http://purl.uniprot.org/citations/25651184 | http://purl.uniprot.org/core/author | "Kockel L."xsd:string |
| http://purl.uniprot.org/citations/25651184 | http://purl.uniprot.org/core/author | "Park S."xsd:string |
| http://purl.uniprot.org/citations/25651184 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/25651184 | http://purl.uniprot.org/core/author | "Gu X."xsd:string |
| http://purl.uniprot.org/citations/25651184 | http://purl.uniprot.org/core/author | "Jain N."xsd:string |
| http://purl.uniprot.org/citations/25651184 | http://purl.uniprot.org/core/author | "Powers A.C."xsd:string |
| http://purl.uniprot.org/citations/25651184 | http://purl.uniprot.org/core/author | "Poffenberger G."xsd:string |
| http://purl.uniprot.org/citations/25651184 | http://purl.uniprot.org/core/author | "Alfa R.W."xsd:string |
| http://purl.uniprot.org/citations/25651184 | http://purl.uniprot.org/core/author | "Skelly K.R."xsd:string |
| http://purl.uniprot.org/citations/25651184 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25651184 | http://purl.uniprot.org/core/name | "Cell Metab"xsd:string |
| http://purl.uniprot.org/citations/25651184 | http://purl.uniprot.org/core/pages | "323-334"xsd:string |
| http://purl.uniprot.org/citations/25651184 | http://purl.uniprot.org/core/title | "Suppression of insulin production and secretion by a decretin hormone."xsd:string |
| http://purl.uniprot.org/citations/25651184 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/25651184 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25651184 |
| http://purl.uniprot.org/citations/25651184 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25651184 |
| http://purl.uniprot.org/uniprot/Q8ITC9#attribution-A9190BB4A3699480379081BD943D5B1C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25651184 |
| http://purl.uniprot.org/uniprot/Q6NPB2#attribution-5F518401BD1EDC192D109C9134EC45DA | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25651184 |
| http://purl.uniprot.org/uniprot/Q6NPB2#attribution-A9190BB4A3699480379081BD943D5B1C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25651184 |
| http://purl.uniprot.org/uniprot/Q6NPB2#attribution-CD674BABAAED35851567CE2ACAE31A2F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25651184 |