| http://purl.uniprot.org/citations/25653391 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25653391 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25653391 | http://www.w3.org/2000/01/rdf-schema#comment | "The inner nuclear membrane proteins emerin and LEMD2 have both overlapping and separate functions in regulation of nuclear organization, gene expression and cell differentiation. We report here that emerin (EMR-1) and LEM domain protein 2 (LEM-2) are expressed in all tissues throughout Caenorhaditis elegans development but their relative distribution differs between cell types. The ratio of EMR-1 to LEM-2 is particularly high in contractile tissues, intermediate in neurons and hypodermis and lowest in intestine and germ line. We find that LEM-2 is recruited earlier than EMR-1 to reforming nuclear envelopes, suggesting the presence of separate mitotic membrane compartments and specific functions of each protein. Concordantly, we observe that nuclei of lem-2 mutant embryos, but not of emr-1 mutants, have reduced nuclear circularity. Finally, we uncover a so-far-unknown role of LEM-2 in nuclear separation and anchoring of microtubule organizing centers."xsd:string |
| http://purl.uniprot.org/citations/25653391 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.164202"xsd:string |
| http://purl.uniprot.org/citations/25653391 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.164202"xsd:string |
| http://purl.uniprot.org/citations/25653391 | http://purl.uniprot.org/core/author | "Askjaer P."xsd:string |
| http://purl.uniprot.org/citations/25653391 | http://purl.uniprot.org/core/author | "Askjaer P."xsd:string |
| http://purl.uniprot.org/citations/25653391 | http://purl.uniprot.org/core/author | "Dobrzynska A."xsd:string |
| http://purl.uniprot.org/citations/25653391 | http://purl.uniprot.org/core/author | "Dobrzynska A."xsd:string |
| http://purl.uniprot.org/citations/25653391 | http://purl.uniprot.org/core/author | "Morales-Martinez A."xsd:string |
| http://purl.uniprot.org/citations/25653391 | http://purl.uniprot.org/core/author | "Morales-Martinez A."xsd:string |
| http://purl.uniprot.org/citations/25653391 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25653391 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25653391 | http://purl.uniprot.org/core/name | "J. Cell Sci."xsd:string |
| http://purl.uniprot.org/citations/25653391 | http://purl.uniprot.org/core/name | "J. Cell Sci."xsd:string |
| http://purl.uniprot.org/citations/25653391 | http://purl.uniprot.org/core/pages | "1090-1096"xsd:string |
| http://purl.uniprot.org/citations/25653391 | http://purl.uniprot.org/core/pages | "1090-1096"xsd:string |
| http://purl.uniprot.org/citations/25653391 | http://purl.uniprot.org/core/title | "Inner nuclear membrane protein LEM-2 is required for correct nuclear separation and morphology in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/25653391 | http://purl.uniprot.org/core/title | "Inner nuclear membrane protein LEM-2 is required for correct nuclear separation and morphology in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/25653391 | http://purl.uniprot.org/core/volume | "128"xsd:string |
| http://purl.uniprot.org/citations/25653391 | http://purl.uniprot.org/core/volume | "128"xsd:string |
| http://purl.uniprot.org/citations/25653391 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25653391 |
| http://purl.uniprot.org/citations/25653391 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25653391 |
| http://purl.uniprot.org/citations/25653391 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25653391 |
| http://purl.uniprot.org/citations/25653391 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25653391 |