| http://purl.uniprot.org/citations/25653593 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25653593 | http://www.w3.org/2000/01/rdf-schema#comment | "Neuronal death induced by overactivation of N-methyl-d-aspartate receptors (NMDARs) is implicated in the pathophysiology of many neurodegenerative diseases such as stroke, epilepsy and traumatic brain injury. This toxic effect is mainly mediated by NR2B-containing extrasynaptic NMDARs, while NR2A-containing synaptic NMDARs contribute to cell survival, suggesting the possibility of therapeutic approaches targeting specific receptor subunits. We report that fractalkine/CX3CL1 protects hippocampal neurons from NMDA-induced cell death with a mechanism requiring the adenosine receptors type 2A (A2AR). This is different from CX3CL1-induced protection from glutamate (Glu)-induced cell death, that fully depends on A1R and requires in part A3R. We show that CX3CL1 neuroprotection against NMDA excitotoxicity involves D-serine, a co-agonist of NR2A/NMDAR, resulting in cyclic AMP-dependent transcription factor cyclic-AMP response element-binding protein (CREB) phosphorylation."xsd:string |
| http://purl.uniprot.org/citations/25653593 | http://purl.org/dc/terms/identifier | "doi:10.3389/fncel.2014.00472"xsd:string |
| http://purl.uniprot.org/citations/25653593 | http://purl.uniprot.org/core/author | "Catalano M."xsd:string |
| http://purl.uniprot.org/citations/25653593 | http://purl.uniprot.org/core/author | "Trettel F."xsd:string |
| http://purl.uniprot.org/citations/25653593 | http://purl.uniprot.org/core/author | "Limatola C."xsd:string |
| http://purl.uniprot.org/citations/25653593 | http://purl.uniprot.org/core/author | "Lauro C."xsd:string |
| http://purl.uniprot.org/citations/25653593 | http://purl.uniprot.org/core/author | "Chece G."xsd:string |
| http://purl.uniprot.org/citations/25653593 | http://purl.uniprot.org/core/author | "Di Paolo E."xsd:string |
| http://purl.uniprot.org/citations/25653593 | http://purl.uniprot.org/core/author | "de Costanzo I."xsd:string |
| http://purl.uniprot.org/citations/25653593 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25653593 | http://purl.uniprot.org/core/name | "Front Cell Neurosci"xsd:string |
| http://purl.uniprot.org/citations/25653593 | http://purl.uniprot.org/core/pages | "472"xsd:string |
| http://purl.uniprot.org/citations/25653593 | http://purl.uniprot.org/core/title | "Fractalkine/CX3CL1 engages different neuroprotective responses upon selective glutamate receptor overactivation."xsd:string |
| http://purl.uniprot.org/citations/25653593 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/25653593 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25653593 |
| http://purl.uniprot.org/citations/25653593 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25653593 |
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