| http://purl.uniprot.org/citations/25654811 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25654811 | http://www.w3.org/2000/01/rdf-schema#comment | "Gastric cancer (GC) is one of the most common malignant tumors worldwide. Emerging evidence has shown that abnormal microRNAs (miRNAs) expression is involved in tumorigenesis. MiR-329 was previously reported to act as a tumor suppressor or oncogene in some types of cancer. However, its function in gastric cancer (GC) is unclear. Here, we found that miR-329 was down-regulated in GC compared with adjacent controls. Enforced expression of miR-329 inhibited proliferation, migration and invasion of gastric cancer cells in vitro. We identified T lymphoma invasion and metastasis 1 (TIAM1) gene as potential target of miR-329. MiR-329 levels inversely correlated with TIAM1 expression in GC. Importantly, TIAM1 rescued the miR-329-mediated inhibition of cell invasion and proliferation. Finally, reintroduction of miR-329 significantly inhibited tumor formation of GC in the xenograft mice. Our findings suggest that miR-329 is a tumor suppressor and potential therapeutic target of GC."xsd:string |
| http://purl.uniprot.org/citations/25654811 | http://purl.org/dc/terms/identifier | "doi:10.18632/oncotarget.2755"xsd:string |
| http://purl.uniprot.org/citations/25654811 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/25654811 | http://purl.uniprot.org/core/author | "Shen J."xsd:string |
| http://purl.uniprot.org/citations/25654811 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/25654811 | http://purl.uniprot.org/core/author | "Yu X."xsd:string |
| http://purl.uniprot.org/citations/25654811 | http://purl.uniprot.org/core/author | "Liang J."xsd:string |
| http://purl.uniprot.org/citations/25654811 | http://purl.uniprot.org/core/author | "Feng F."xsd:string |
| http://purl.uniprot.org/citations/25654811 | http://purl.uniprot.org/core/author | "Wu W.K."xsd:string |
| http://purl.uniprot.org/citations/25654811 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25654811 | http://purl.uniprot.org/core/name | "Oncotarget"xsd:string |
| http://purl.uniprot.org/citations/25654811 | http://purl.uniprot.org/core/pages | "17559-17569"xsd:string |
| http://purl.uniprot.org/citations/25654811 | http://purl.uniprot.org/core/title | "By downregulating TIAM1 expression, microRNA-329 suppresses gastric cancer invasion and growth."xsd:string |
| http://purl.uniprot.org/citations/25654811 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/25654811 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25654811 |
| http://purl.uniprot.org/citations/25654811 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25654811 |
| http://purl.uniprot.org/uniprot/#_A0A8V8TN84-mappedCitation-25654811 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25654811 |
| http://purl.uniprot.org/uniprot/#_A0A2X0TW27-mappedCitation-25654811 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25654811 |
| http://purl.uniprot.org/uniprot/#_Q13009-mappedCitation-25654811 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25654811 |
| http://purl.uniprot.org/uniprot/#_Q59GK8-mappedCitation-25654811 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25654811 |
| http://purl.uniprot.org/uniprot/A0A8V8TN84 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25654811 |
| http://purl.uniprot.org/uniprot/Q13009 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25654811 |
| http://purl.uniprot.org/uniprot/Q59GK8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25654811 |
| http://purl.uniprot.org/uniprot/A0A2X0TW27 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25654811 |