| http://purl.uniprot.org/citations/25656814 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25656814 | http://www.w3.org/2000/01/rdf-schema#comment | "Fetuin-A, a serum protein that regulates calcium mineralization, has been associated with bone mineral density (BMD) in several cross-sectional human studies, suggesting a possible beneficial effect on clinically important measures of bone health. Fetuin-A and incidence of subsequent fracture was assessed in 4714 men and women ≥65 years of age. Proportional hazards models were used to estimate risk of incident hip (hospital discharge ICD-9 codes) and composite fracture (hip, pelvis, humerus, or proximal forearm; hospital discharge ICD-9 codes and Medicare claims data). A total of 576 participants had an incident hip fracture (median follow-up 11.2 years) and 768 had an incident composite fracture (median follow-up 6.9 years). In unadjusted analyses, there was no association between fetuin-A (per SD increase) and risk of hip fracture (hazard ratio [HR], 0.96; 95% CI, 0.88 to 1.05) or composite fracture (HR, 0.99; 95% CI, 0.92 to 1.06). Results were not significantly changed after adjustment for potential confounding variables. Analyses modeling fetuin-A in quartiles or within a subset with available BMD measures also showed no statistically significant association with risk of hip or composite fracture. Though fetuin-A was positively associated with areal BMD in partially adjusted models (total hip: β, 0.013 g/cm(2) ; 95% CI, 0.005 to 0.021; femoral neck: β, 0.011 g/cm(2) ; 95% CI, 0.004 to 0.018; and lumbar spine: β, 0.007 g/cm(2) ; 95% CI, 0.001 to 0.028), these associations were no longer significant after further adjustment for BMI and in final multivariate models. In this large sample of community-dwelling older adults, a small positive association between fetuin-A and areal BMD appeared attributable to confounding variables and we found no evidence of an association between fetuin-A and risk of clinical fracture."xsd:string |
| http://purl.uniprot.org/citations/25656814 | http://purl.org/dc/terms/identifier | "doi:10.1002/jbmr.2475"xsd:string |
| http://purl.uniprot.org/citations/25656814 | http://purl.uniprot.org/core/author | "Cauley J.A."xsd:string |
| http://purl.uniprot.org/citations/25656814 | http://purl.uniprot.org/core/author | "Kizer J.R."xsd:string |
| http://purl.uniprot.org/citations/25656814 | http://purl.uniprot.org/core/author | "Jalal D.I."xsd:string |
| http://purl.uniprot.org/citations/25656814 | http://purl.uniprot.org/core/author | "Ix J.H."xsd:string |
| http://purl.uniprot.org/citations/25656814 | http://purl.uniprot.org/core/author | "Mukamal K.J."xsd:string |
| http://purl.uniprot.org/citations/25656814 | http://purl.uniprot.org/core/author | "Buzkova P."xsd:string |
| http://purl.uniprot.org/citations/25656814 | http://purl.uniprot.org/core/author | "Barzilay J.I."xsd:string |
| http://purl.uniprot.org/citations/25656814 | http://purl.uniprot.org/core/author | "Fink H.A."xsd:string |
| http://purl.uniprot.org/citations/25656814 | http://purl.uniprot.org/core/author | "Garimella P.S."xsd:string |
| http://purl.uniprot.org/citations/25656814 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25656814 | http://purl.uniprot.org/core/name | "J Bone Miner Res"xsd:string |
| http://purl.uniprot.org/citations/25656814 | http://purl.uniprot.org/core/pages | "1394-1402"xsd:string |
| http://purl.uniprot.org/citations/25656814 | http://purl.uniprot.org/core/title | "Association of Fetuin-A With Incident Fractures in Community-Dwelling Older Adults: The Cardiovascular Health Study."xsd:string |
| http://purl.uniprot.org/citations/25656814 | http://purl.uniprot.org/core/volume | "30"xsd:string |
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