DESCRIBE <http://purl.uniprot.org/citations/25660097>

Subject	Predicate	Object
http://purl.uniprot.org/citations/25660097	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/25660097	http://www.w3.org/2000/01/rdf-schema#comment	" Introduction Prostate cancer is the most frequent malignancy found to occur in Caucasian men, but its genetic basis remains elusive. A prostate cancer-susceptibility locus has been identified on chromosome 13q14. The tumour suppressor gene deleted in cancer cells 1 (DICE1/INTS6) is located within this interval on 13q14.3. Materials and methods We performed mutation analysis of the DICE1/INTS6 gene in thirteen German prostate cancer families. Results and conclusion None of the patients harboured DICE1 mutations, and similar frequencies of the previously identified 13 bp deletion polymorphism in the DICE1 promoter were observed in the familial prostate cancer patients as compared with sporadic prostate cancer patients and controls. However, in one family with three affected brothers, the variations c.1215A>C (p.T405T) in exon 10 and c.2568A>G (p.S856S) in exon 17 were detected in a heterozygous pattern. In sporadic prostate cancer patients, variant c.2568A>G (p.S856S) was detected in 10/325 (3.08%) compared with 5/207 (2.42%) control samples (p > 0.05). We conclude that DICE1 appears to be involved in prostate cancer progression rather than in the initiation of prostate cancer."xsd:string
http://purl.uniprot.org/citations/25660097	http://purl.org/dc/terms/identifier	"doi:10.1159/000366229"xsd:string
http://purl.uniprot.org/citations/25660097	http://purl.uniprot.org/core/author	"Maier C."xsd:string
http://purl.uniprot.org/citations/25660097	http://purl.uniprot.org/core/author	"Wieland I."xsd:string
http://purl.uniprot.org/citations/25660097	http://purl.uniprot.org/core/author	"Vogel W."xsd:string
http://purl.uniprot.org/citations/25660097	http://purl.uniprot.org/core/author	"Bohm M."xsd:string
http://purl.uniprot.org/citations/25660097	http://purl.uniprot.org/core/author	"Ropke A."xsd:string
http://purl.uniprot.org/citations/25660097	http://purl.uniprot.org/core/author	"Kufer R."xsd:string
http://purl.uniprot.org/citations/25660097	http://purl.uniprot.org/core/date	"2015"xsd:gYear
http://purl.uniprot.org/citations/25660097	http://purl.uniprot.org/core/name	"Urol Int"xsd:string
http://purl.uniprot.org/citations/25660097	http://purl.uniprot.org/core/pages	"386-389"xsd:string
http://purl.uniprot.org/citations/25660097	http://purl.uniprot.org/core/title	"Genetic Variants of DICE1/INTS6 in German Prostate Cancer Families with Linkage to 13q14."xsd:string
http://purl.uniprot.org/citations/25660097	http://purl.uniprot.org/core/volume	"95"xsd:string
http://purl.uniprot.org/citations/25660097	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/25660097
http://purl.uniprot.org/citations/25660097	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/25660097
http://purl.uniprot.org/uniprot/#_B3KU90-mappedCitation-25660097	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/25660097
http://purl.uniprot.org/uniprot/#_B4E2C8-mappedCitation-25660097	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/25660097
http://purl.uniprot.org/uniprot/#_B4E1J5-mappedCitation-25660097	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/25660097
http://purl.uniprot.org/uniprot/#_B4DL13-mappedCitation-25660097	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/25660097
http://purl.uniprot.org/uniprot/#_G5E9X1-mappedCitation-25660097	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/25660097
http://purl.uniprot.org/uniprot/#_Q9UL03-mappedCitation-25660097	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/25660097
http://purl.uniprot.org/uniprot/B4E1J5	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/25660097
http://purl.uniprot.org/uniprot/G5E9X1	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/25660097
http://purl.uniprot.org/uniprot/B4E2C8	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/25660097