| http://purl.uniprot.org/citations/25661196 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25661196 | http://www.w3.org/2000/01/rdf-schema#comment | "Cystic Fibrosis (CF) disease is caused by mutations in the CFTR gene (CF transmembrane conductance regulator). F508 deletion is the most represented mutation, and F508del-CFTR is absent of plasma membrane and accumulates into the endoplasmic reticulum (ER) compartment. Using specific Ca2+ genetics cameleon probes, we showed in the human bronchial CF epithelial cell line CFBE that ER Ca2+ concentration was strongly increased compared to non-CF (16HBE) cells, and normalized by the F508del-CFTR corrector agent, VX-809. We also showed that ER F508del-CFTR retention increases SERCA (Sarcoplasmic/Reticulum Ca2+ ATPase) pump activity whereas PMCA (Plasma Membrane Ca2+ ATPase) activities were reduced in these CF cells compared to corrected CF cells (VX-809) and non-CF cells. We are showing for the first time CFTR/SERCA and CFTR/PMCA interactions that are modulated in CF cells and could explain part of Ca2+ homeostasis deregulation due to mislocalization of F508del-CFTR. Using ER or mitochondria genetics Ca2+ probes, we are showing that ER Ca2+ content, mitochondrial Ca2+ uptake, SERCA and PMCA pump, activities are strongly affected by the localization of F508del-CFTR protein."xsd:string |
| http://purl.uniprot.org/citations/25661196 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbamcr.2015.01.010"xsd:string |
| http://purl.uniprot.org/citations/25661196 | http://purl.uniprot.org/core/author | "Philippe R."xsd:string |
| http://purl.uniprot.org/citations/25661196 | http://purl.uniprot.org/core/author | "Becq F."xsd:string |
| http://purl.uniprot.org/citations/25661196 | http://purl.uniprot.org/core/author | "Norez C."xsd:string |
| http://purl.uniprot.org/citations/25661196 | http://purl.uniprot.org/core/author | "Antigny F."xsd:string |
| http://purl.uniprot.org/citations/25661196 | http://purl.uniprot.org/core/author | "Frieden M."xsd:string |
| http://purl.uniprot.org/citations/25661196 | http://purl.uniprot.org/core/author | "Mignen O."xsd:string |
| http://purl.uniprot.org/citations/25661196 | http://purl.uniprot.org/core/author | "Buscaglia P."xsd:string |
| http://purl.uniprot.org/citations/25661196 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25661196 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta"xsd:string |
| http://purl.uniprot.org/citations/25661196 | http://purl.uniprot.org/core/pages | "892-903"xsd:string |
| http://purl.uniprot.org/citations/25661196 | http://purl.uniprot.org/core/title | "SERCA and PMCA pumps contribute to the deregulation of Ca2+ homeostasis in human CF epithelial cells."xsd:string |
| http://purl.uniprot.org/citations/25661196 | http://purl.uniprot.org/core/volume | "1853"xsd:string |
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