| http://purl.uniprot.org/citations/25662274 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25662274 | http://www.w3.org/2000/01/rdf-schema#comment | "In mouse steroidogenic cells the activation of cholesterol metabolism is mediated by steroidogenic acute regulatory protein (StAR). Here, we visualized a coordinated regulation of StAR transcription, splicing and post-transcriptional processing, which are synchronized by salt inducible kinase (SIK1) and CREB-regulated transcription coactivator (CRTC2). To detect primary RNA (pRNA), spliced primary RNA (Sp-RNA) and mRNA in single cells, we generated probe sets by using fluorescence in situ hybridization (FISH). These methods allowed us to address the nature of StAR gene expression and to visualize protein-nucleic acid interactions through direct detection. We show that SIK1 represses StAR expression in Y1 adrenal and MA10 testis cells through inhibition of processing mediated by CRTC2. Digital image analysis matches qPCR analyses of the total cell culture. Evidence is presented for spatially separate accumulation of StAR pRNA and Sp-RNA at the gene loci in the nucleus. These findings establish that cAMP, SIK and CRTC mediate StAR expression through activation of individual StAR gene loci."xsd:string |
| http://purl.uniprot.org/citations/25662274 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mce.2015.01.022"xsd:string |
| http://purl.uniprot.org/citations/25662274 | http://purl.uniprot.org/core/author | "Lee J."xsd:string |
| http://purl.uniprot.org/citations/25662274 | http://purl.uniprot.org/core/author | "Takemori H."xsd:string |
| http://purl.uniprot.org/citations/25662274 | http://purl.uniprot.org/core/author | "Tong T."xsd:string |
| http://purl.uniprot.org/citations/25662274 | http://purl.uniprot.org/core/author | "Jefcoate C."xsd:string |
| http://purl.uniprot.org/citations/25662274 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25662274 | http://purl.uniprot.org/core/name | "Mol Cell Endocrinol"xsd:string |
| http://purl.uniprot.org/citations/25662274 | http://purl.uniprot.org/core/pages | "80-89"xsd:string |
| http://purl.uniprot.org/citations/25662274 | http://purl.uniprot.org/core/title | "Stimulation of StAR expression by cAMP is controlled by inhibition of highly inducible SIK1 via CRTC2, a co-activator of CREB."xsd:string |
| http://purl.uniprot.org/citations/25662274 | http://purl.uniprot.org/core/volume | "408"xsd:string |
| http://purl.uniprot.org/citations/25662274 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25662274 |
| http://purl.uniprot.org/citations/25662274 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25662274 |
| http://purl.uniprot.org/uniprot/#_Q62347-mappedCitation-25662274 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25662274 |
| http://purl.uniprot.org/uniprot/#_Q3U182-mappedCitation-25662274 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25662274 |
| http://purl.uniprot.org/uniprot/#_Q60670-mappedCitation-25662274 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25662274 |
| http://purl.uniprot.org/uniprot/#_Q61440-mappedCitation-25662274 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25662274 |
| http://purl.uniprot.org/uniprot/#_Q61441-mappedCitation-25662274 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25662274 |
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| http://purl.uniprot.org/uniprot/#_Q61443-mappedCitation-25662274 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25662274 |
| http://purl.uniprot.org/uniprot/#_P51557-mappedCitation-25662274 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25662274 |
| http://purl.uniprot.org/uniprot/#_P70300-mappedCitation-25662274 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25662274 |
| http://purl.uniprot.org/uniprot/#_Q01147-mappedCitation-25662274 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25662274 |
| http://purl.uniprot.org/uniprot/#_Q3TDX5-mappedCitation-25662274 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25662274 |