| http://purl.uniprot.org/citations/25666200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25666200 | http://www.w3.org/2000/01/rdf-schema#comment | "Human leukocyte antigen (HLA) alleles are associated with both the progression of chronic hepatitis C (CHC) and the sustained virological response (SVR) to antiviral therapy. HLA-A*02 is the most common HLA allele in people of European/Caucasian descent and the Chinese and Japanese population. Therefore, we investigated whether HLA-A*02 expression is associated with disease outcome in Chinese CHC patients. Three hundred thirty-one treatment-naïve CHC patients were recruited in this study. The expression of HLA-A*02 was tested by FACS and LABType SSO assays. All patients were treated weekly with pegylated interferon plus ribavirin (PEG-IFN/RBV) according to a standard protocol. Virological response was assessed by TaqMan assay at the 4th, 12th, 24th, and 48th week of therapy, and again at the 24th week post-therapy. By the end of the study, 293 CHC patients, including 144 HLA-A*02-positive patients and 149 HLA-A*02-negative patients, were evaluable for analysis. There were no statistical differences in clinicopathological parameters between HLA-A*02-positive and negative patients before antiviral therapy (P > 0.05). The HLA-A*02-positive patients had a higher rapid virological response (RVR, 74.3 % versus 62.4 %, P = 0.03) and SVR (78.5 % versus 64.4 %, P = 0.01) and a lower relapse rate (4.2 % versus 11.9 %, P = 0.03) than HLA-A*02-negative patients. Multivariable logistic regression analysis showed that HLA-A*02 expression, liver fibrosis stages xsd:string |
| http://purl.uniprot.org/citations/25666200 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00705-015-2361-y"xsd:string |
| http://purl.uniprot.org/citations/25666200 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/25666200 | http://purl.uniprot.org/core/author | "Wang M."xsd:string |
| http://purl.uniprot.org/citations/25666200 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/25666200 | http://purl.uniprot.org/core/author | "Wang F."xsd:string |
| http://purl.uniprot.org/citations/25666200 | http://purl.uniprot.org/core/author | "Guo Q."xsd:string |
| http://purl.uniprot.org/citations/25666200 | http://purl.uniprot.org/core/author | "Islam M.S."xsd:string |
| http://purl.uniprot.org/citations/25666200 | http://purl.uniprot.org/core/author | "Li J.S."xsd:string |
| http://purl.uniprot.org/citations/25666200 | http://purl.uniprot.org/core/author | "Zhang T.F."xsd:string |
| http://purl.uniprot.org/citations/25666200 | http://purl.uniprot.org/core/author | "Ping Y."xsd:string |
| http://purl.uniprot.org/citations/25666200 | http://purl.uniprot.org/core/author | "Li Z.Q."xsd:string |
| http://purl.uniprot.org/citations/25666200 | http://purl.uniprot.org/core/author | "Wang L.P."xsd:string |
| http://purl.uniprot.org/citations/25666200 | http://purl.uniprot.org/core/author | "Yue D.L."xsd:string |
| http://purl.uniprot.org/citations/25666200 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25666200 | http://purl.uniprot.org/core/name | "Arch Virol"xsd:string |
| http://purl.uniprot.org/citations/25666200 | http://purl.uniprot.org/core/pages | "1043-1054"xsd:string |
| http://purl.uniprot.org/citations/25666200 | http://purl.uniprot.org/core/title | "The host HLA-A*02 allele is associated with the response to pegylated interferon and ribavirin in patients with chronic hepatitis C virus infection."xsd:string |
| http://purl.uniprot.org/citations/25666200 | http://purl.uniprot.org/core/volume | "160"xsd:string |
| http://purl.uniprot.org/citations/25666200 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25666200 |
| http://purl.uniprot.org/citations/25666200 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25666200 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C543-mappedCitation-25666200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25666200 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C548-mappedCitation-25666200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25666200 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C551-mappedCitation-25666200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25666200 |