| http://purl.uniprot.org/citations/25666256 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25666256 | http://www.w3.org/2000/01/rdf-schema#comment | "Constitutive activation of Janus kinase 2/signal transducers and activators of transcription (JAK2/STAT) signaling caused by JAK2V617F and other mutations is central to the pathogenesis of myeloproliferative neoplasm (MPN). Negative regulators such as suppressors of cytokine signaling (SOCS) inhibit activated JAK2/STAT signaling. However, whether silencing of negative regulators facilitates JAK2/STAT signaling is unclear. Here, we report that loss of miR-375 expression contributes to the constitutive activation of JAK2/STAT signaling. MiR-375 reduced JAK2 protein level and repressed the activity of a luciferase reporter by binding 3'-untranslated regions, which was abolished by the mutation of the predicted miR-375-binding site. Meanwhile, a significant inverse correlation between the expressions of miR-375 and JAK2 was found in multiple types of leukemic cell lines and bone marrow mononuclear cells from MPN patients, suggesting that JAK2 may be a miR-375 target gene. Furthermore, forced expression of miR-375 inhibited constitutive and inducible JAK2/STAT signaling, suppressed cell proliferation, and decreased colony formation in hematopoietic progenitors from MPN patients. Finally, histone deacetylation (HDAC) inhibitors restored miR-375 expression, which was much lower in patients with MPN compared with healthy volunteers. Collectively, our data suggest that the loss of miR-375 expression enhances the constitutive and persistent activation of JAK2/STAT signaling. Restoration of miR-375 expression might contribute to the clinical treatment for MPN patients."xsd:string |
| http://purl.uniprot.org/citations/25666256 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.leukres.2015.01.009"xsd:string |
| http://purl.uniprot.org/citations/25666256 | http://purl.uniprot.org/core/author | "Shi Y.F."xsd:string |
| http://purl.uniprot.org/citations/25666256 | http://purl.uniprot.org/core/author | "Li H.Y."xsd:string |
| http://purl.uniprot.org/citations/25666256 | http://purl.uniprot.org/core/author | "Yin L.H."xsd:string |
| http://purl.uniprot.org/citations/25666256 | http://purl.uniprot.org/core/author | "Wu J.B."xsd:string |
| http://purl.uniprot.org/citations/25666256 | http://purl.uniprot.org/core/author | "Gao S.M."xsd:string |
| http://purl.uniprot.org/citations/25666256 | http://purl.uniprot.org/core/author | "Zheng X.Q."xsd:string |
| http://purl.uniprot.org/citations/25666256 | http://purl.uniprot.org/core/author | "Bi L.X."xsd:string |
| http://purl.uniprot.org/citations/25666256 | http://purl.uniprot.org/core/author | "Ye A.F."xsd:string |
| http://purl.uniprot.org/citations/25666256 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25666256 | http://purl.uniprot.org/core/name | "Leuk Res"xsd:string |
| http://purl.uniprot.org/citations/25666256 | http://purl.uniprot.org/core/pages | "471-478"xsd:string |
| http://purl.uniprot.org/citations/25666256 | http://purl.uniprot.org/core/title | "Epigenetic deregulated miR-375 contributes to the constitutive activation of JAK2/STAT signaling in myeloproliferative neoplasm."xsd:string |
| http://purl.uniprot.org/citations/25666256 | http://purl.uniprot.org/core/volume | "39"xsd:string |
| http://purl.uniprot.org/citations/25666256 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25666256 |
| http://purl.uniprot.org/citations/25666256 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25666256 |
| http://purl.uniprot.org/uniprot/#_B7ZA24-mappedCitation-25666256 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25666256 |
| http://purl.uniprot.org/uniprot/#_A9QVL8-mappedCitation-25666256 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25666256 |
| http://purl.uniprot.org/uniprot/#_A0A7I2V395-mappedCitation-25666256 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25666256 |
| http://purl.uniprot.org/uniprot/#_A8K910-mappedCitation-25666256 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25666256 |
| http://purl.uniprot.org/uniprot/#_B4DNP0-mappedCitation-25666256 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25666256 |
| http://purl.uniprot.org/uniprot/#_B4DVR6-mappedCitation-25666256 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25666256 |
| http://purl.uniprot.org/uniprot/#_B4DYV1-mappedCitation-25666256 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25666256 |