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| http://purl.uniprot.org/citations/25666348 | http://www.w3.org/2000/01/rdf-schema#comment | "Germline mutations in the breast cancer type 2 susceptibility gene (BRCA2) are linked to familial breast cancer and the progressive bone marrow failure syndrome Fanconi anaemia. Established Brca2 mouse knockout models show embryonic lethality, but those with a truncating mutation at the C-terminus survive to birth and develop thymic lymphoma at an early age. To overcome early lethality and investigate the function of BRCA2, we used T cell-specific conditional Brca2 knockout mice, which were previously shown to develop thymic lymphoma at a low penetrance. In the current study we showed that the number of peripheral T cells, particularly naïve pools, drastically declined with age. This decline was primarily ascribed to improper peripheral maintenance. Furthermore, heterozygous mice with one wild-type Brca2 allele manifested reduced T cell numbers, suggesting that Brca2 haploinsufficiency might also result in T cell loss. Our study reveals molecular events occurring in Brca2-deficient T cells and suggests that both heterozygous and homozygous Brca2 mutation may lead to dysfunction in T cell populations."xsd:string |
| http://purl.uniprot.org/citations/25666348 | http://purl.org/dc/terms/identifier | "doi:10.14348/molcells.2015.2302"xsd:string |
| http://purl.uniprot.org/citations/25666348 | http://purl.uniprot.org/core/author | "Lee H."xsd:string |
| http://purl.uniprot.org/citations/25666348 | http://purl.uniprot.org/core/author | "Park P."xsd:string |
| http://purl.uniprot.org/citations/25666348 | http://purl.uniprot.org/core/author | "Jeong J.H."xsd:string |
| http://purl.uniprot.org/citations/25666348 | http://purl.uniprot.org/core/author | "Jo A."xsd:string |
| http://purl.uniprot.org/citations/25666348 | http://purl.uniprot.org/core/author | "Lee H.O."xsd:string |
| http://purl.uniprot.org/citations/25666348 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25666348 | http://purl.uniprot.org/core/name | "Mol Cells"xsd:string |
| http://purl.uniprot.org/citations/25666348 | http://purl.uniprot.org/core/pages | "251-258"xsd:string |
| http://purl.uniprot.org/citations/25666348 | http://purl.uniprot.org/core/title | "Brca2 deficiency leads to T cell loss and immune dysfunction."xsd:string |
| http://purl.uniprot.org/citations/25666348 | http://purl.uniprot.org/core/volume | "38"xsd:string |
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