| http://purl.uniprot.org/citations/25666956 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25666956 | http://www.w3.org/2000/01/rdf-schema#comment | "In the present study, we report the first DNA analysis of HLA class I and class II alleles in Macedonian autistic subjects. We have analyzed the HLA-A, -C, -B, DRB1 genotypes of 35 autistic patients, and 98 healthy unrelated Macedonians (control group). HLA DNA typing of class I genes was performed using a Reverse Line Strip method (RLS), and the Sequencing Based Typing method (SBT) was used for typing of class II genes. In the autistic subjects for HLA-A locus 14 alleles have been identified with 2 being predominant *02 (25.7 %), and *24 (18.6 %). Among the 11 identified HLA-C alleles, 3 were predominant such as *12 (20.0 %), *07 (17.1 %), and *03 (12.9 %). Among the 18 identified HLA-B alleles, 2 were predominant: *51 (18.6 %), and *18 (11.4 %). For HLA-DRB1 locus, 10 alleles have been identified with 2 of them predominant such as: *11 (21.4 %), and *01 (14.3 %). The allele and haplotype frequencies in the patients group were compared to those of 98 control subjects. Our results showed significantly increased frequencies of HLA-C*03 (OR = 2.74*; χ2 = 4.68; p = 0.03), and HLA-DRB1*01 (OR = 3.10*; χ2 = 6.26; p = 0.012) alleles in autistic patients when compared to the controls. The most frequent haplotype frequencies in autistic sample were A*11-C*12-B*52-DRB1*15 (2.9 %), A*24-C*03-B*55-DRB1*16 (2.9 %), and A*24-C*03-B*55-DRB1*16 (2.9 %), but they were not statistically significant when compared to the control group. None of our patients carried allele or haplotype, which were protective in our population. Hardy-Weinberg equilibrium in autistic group showed that HLA-A (p < 0.03), HLA-C (p < 0.04), and HLA-DRB1 (p < 0.002) loci were in linkage disequilibria. In the control group, we found only for the HLA-DRB1 locus linkage disequilibrium (p < 0.002). Our results demonstrated the association of HLA-C*03 and HLA-DRB1*01 alleles with Macedonian autistic patients (Tab. 7, Ref. 37)."xsd:string |
| http://purl.uniprot.org/citations/25666956 | http://purl.org/dc/terms/identifier | "doi:10.4149/bll_2015_003"xsd:string |
| http://purl.uniprot.org/citations/25666956 | http://purl.uniprot.org/core/author | "Spiroski M."xsd:string |
| http://purl.uniprot.org/citations/25666956 | http://purl.uniprot.org/core/author | "Trajkovski V."xsd:string |
| http://purl.uniprot.org/citations/25666956 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25666956 | http://purl.uniprot.org/core/name | "Bratisl Lek Listy"xsd:string |
| http://purl.uniprot.org/citations/25666956 | http://purl.uniprot.org/core/pages | "14-19"xsd:string |
| http://purl.uniprot.org/citations/25666956 | http://purl.uniprot.org/core/title | "DNA typing of HLA-A, -C, -B, AND -DRB1 in the children with autism in the Republic of Macedonia."xsd:string |
| http://purl.uniprot.org/citations/25666956 | http://purl.uniprot.org/core/volume | "116"xsd:string |
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