| http://purl.uniprot.org/citations/25669982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25669982 | http://www.w3.org/2000/01/rdf-schema#comment | "Tylophorine compounds have been the focus of drug development for decades. Tylophorine derivatives exhibit anti-cancer activities but their cellular targets remain unknown. We used a biotinylated tylophorine derivative to probe for the interacting cellular target(s) of tylophorine. Tylophorine directly binds to caprin-1 and consequently enhances the recruitment of G3BP1, c-Myc mRNA, and cyclin D2 mRNA to form a ribonucleoprotein complex. Subsequently, this tylophorine targeted ribonucleoprotein complex is sequestered to the polysomal fractions and the protein expressions of the associated mRNA-transcripts are repressed. Caprin-1 depleted carcinoma cells become more resistant to tylophorine, associated with decreased formation of the ribonucleoprotein complex targeted by tylophorine. Consequently, tylophorine downregulates c-Myc and cyclins D1/D2, causing hypophosphorylation of Rb and suppression of both processing-body formation and the Warburg effect. Gene expression profiling and gain-of-c-Myc-function experiments also revealed that the downregulated c-Myc contributes to the anti-oncogenic effects of tylophorine compounds. Furthermore, the potent tylophorine derivative dibenzoquinoline-33b elicited a similar effect, as c-Myc protein levels were also decreased in xenograft tumors treated with dibenzoquinoline-33b. Thus, tylophorine compounds exert anti-cancer activity predominantly by targeting and sequestering the caprin-1 protein and c-Myc mRNA associated ribonucleoprotein complex."xsd:string |
| http://purl.uniprot.org/citations/25669982 | http://purl.org/dc/terms/identifier | "doi:10.18632/oncotarget.3236"xsd:string |
| http://purl.uniprot.org/citations/25669982 | http://purl.uniprot.org/core/author | "Hsu H.Y."xsd:string |
| http://purl.uniprot.org/citations/25669982 | http://purl.uniprot.org/core/author | "Lee S.J."xsd:string |
| http://purl.uniprot.org/citations/25669982 | http://purl.uniprot.org/core/author | "Yang R.B."xsd:string |
| http://purl.uniprot.org/citations/25669982 | http://purl.uniprot.org/core/author | "Lee C.H."xsd:string |
| http://purl.uniprot.org/citations/25669982 | http://purl.uniprot.org/core/author | "Chang C.C."xsd:string |
| http://purl.uniprot.org/citations/25669982 | http://purl.uniprot.org/core/author | "Lee Y.Z."xsd:string |
| http://purl.uniprot.org/citations/25669982 | http://purl.uniprot.org/core/author | "Yang C.W."xsd:string |
| http://purl.uniprot.org/citations/25669982 | http://purl.uniprot.org/core/author | "Qiu Y.Q."xsd:string |
| http://purl.uniprot.org/citations/25669982 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25669982 | http://purl.uniprot.org/core/name | "Oncotarget"xsd:string |
| http://purl.uniprot.org/citations/25669982 | http://purl.uniprot.org/core/pages | "2148-2163"xsd:string |
| http://purl.uniprot.org/citations/25669982 | http://purl.uniprot.org/core/title | "Targeting a ribonucleoprotein complex containing the caprin-1 protein and the c-Myc mRNA suppresses tumor growth in mice: an identification of a novel oncotarget."xsd:string |
| http://purl.uniprot.org/citations/25669982 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/25669982 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25669982 |
| http://purl.uniprot.org/citations/25669982 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25669982 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1R1-mappedCitation-25669982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25669982 |
| http://purl.uniprot.org/uniprot/#_A0N2G3-mappedCitation-25669982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25669982 |
| http://purl.uniprot.org/uniprot/#_A0A224B085-mappedCitation-25669982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25669982 |
| http://purl.uniprot.org/uniprot/#_B3CJ86-mappedCitation-25669982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25669982 |
| http://purl.uniprot.org/uniprot/#_B3CJ87-mappedCitation-25669982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25669982 |
| http://purl.uniprot.org/uniprot/#_B3CJ88-mappedCitation-25669982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25669982 |
| http://purl.uniprot.org/uniprot/#_B3CJB3-mappedCitation-25669982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25669982 |