| http://purl.uniprot.org/citations/25671546 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25671546 | http://www.w3.org/2000/01/rdf-schema#comment | "Analyses of gene expression profiles in evolutionarily diverse organisms have revealed a role for microRNAs in tuning tissue-specific gene expression. Here, we show that the relatively abundant and constitutively expressed miR-58 family of microRNAs sharply defines the tissue-specific expression of the broadly transcribed gene encoding PMK-2 p38 MAPK in Caenorhabditis elegans. Whereas PMK-2 functions redundantly with PMK-1 in the nervous system to regulate neuronal development and behavioral responses to pathogenic bacteria, the miR-58, miR-80, miR-81, and miR-82 microRNAs function redundantly to destabilize pmk-2 mRNA in non-neuronal cells with switch-like potency. Our data suggest a role for the miR-58 family in the establishment of neuronal-specific gene expression in C. elegans, and support a more general role for microRNAs in the establishment of tissue-specific gene expression."xsd:string |
| http://purl.uniprot.org/citations/25671546 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1004997"xsd:string |
| http://purl.uniprot.org/citations/25671546 | http://purl.uniprot.org/core/author | "Kim D.H."xsd:string |
| http://purl.uniprot.org/citations/25671546 | http://purl.uniprot.org/core/author | "Kingston E.R."xsd:string |
| http://purl.uniprot.org/citations/25671546 | http://purl.uniprot.org/core/author | "Pagano D.J."xsd:string |
| http://purl.uniprot.org/citations/25671546 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25671546 | http://purl.uniprot.org/core/name | "PLoS Genet"xsd:string |
| http://purl.uniprot.org/citations/25671546 | http://purl.uniprot.org/core/pages | "e1004997"xsd:string |
| http://purl.uniprot.org/citations/25671546 | http://purl.uniprot.org/core/title | "Tissue expression pattern of PMK-2 p38 MAPK is established by the miR-58 family in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/25671546 | http://purl.uniprot.org/core/volume | "11"xsd:string |
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