| http://purl.uniprot.org/citations/25678324 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25678324 | http://www.w3.org/2000/01/rdf-schema#comment | "Impairment of synaptic function can lead to neuropsychiatric disorders collectively referred to as synaptopathies. The SNARE protein SNAP-25 is implicated in several brain pathologies and, indeed, brain areas of psychiatric patients often display reduced SNAP-25 expression. It has been recently found that acute downregulation of SNAP-25 in brain slices impairs long-term potentiation; however, the processes through which this occurs are still poorly defined. We show that in vivo acute downregulation of SNAP-25 in CA1 hippocampal region affects spine number. Consistently, hippocampal neurons from SNAP-25 heterozygous mice show reduced densities of dendritic spines and defective PSD-95 dynamics. Finally, we show that, in brain, SNAP-25 is part of a molecular complex including PSD-95 and p140Cap, with p140Cap being capable to bind to both SNAP-25 and PSD-95. These data demonstrate an unexpected role of SNAP-25 in controlling PSD-95 clustering and open the possibility that genetic reductions of the protein levels - as occurring in schizophrenia - may contribute to the pathology through an effect on postsynaptic function and plasticity."xsd:string |
| http://purl.uniprot.org/citations/25678324 | http://purl.org/dc/terms/identifier | "doi:10.1038/cdd.2014.227"xsd:string |
| http://purl.uniprot.org/citations/25678324 | http://purl.uniprot.org/core/author | "Sharma V."xsd:string |
| http://purl.uniprot.org/citations/25678324 | http://purl.uniprot.org/core/author | "Rosenblum K."xsd:string |
| http://purl.uniprot.org/citations/25678324 | http://purl.uniprot.org/core/author | "Fossati G."xsd:string |
| http://purl.uniprot.org/citations/25678324 | http://purl.uniprot.org/core/author | "Wanker E.E."xsd:string |
| http://purl.uniprot.org/citations/25678324 | http://purl.uniprot.org/core/author | "Ziv N.E."xsd:string |
| http://purl.uniprot.org/citations/25678324 | http://purl.uniprot.org/core/author | "Brambilla R."xsd:string |
| http://purl.uniprot.org/citations/25678324 | http://purl.uniprot.org/core/author | "Turco E."xsd:string |
| http://purl.uniprot.org/citations/25678324 | http://purl.uniprot.org/core/author | "Defilippi P."xsd:string |
| http://purl.uniprot.org/citations/25678324 | http://purl.uniprot.org/core/author | "Matteoli M."xsd:string |
| http://purl.uniprot.org/citations/25678324 | http://purl.uniprot.org/core/author | "Menna E."xsd:string |
| http://purl.uniprot.org/citations/25678324 | http://purl.uniprot.org/core/author | "Meier J.C."xsd:string |
| http://purl.uniprot.org/citations/25678324 | http://purl.uniprot.org/core/author | "Antonucci F."xsd:string |
| http://purl.uniprot.org/citations/25678324 | http://purl.uniprot.org/core/author | "Pozzi D."xsd:string |
| http://purl.uniprot.org/citations/25678324 | http://purl.uniprot.org/core/author | "Corradini I."xsd:string |
| http://purl.uniprot.org/citations/25678324 | http://purl.uniprot.org/core/author | "Morini R."xsd:string |
| http://purl.uniprot.org/citations/25678324 | http://purl.uniprot.org/core/author | "Edry E."xsd:string |
| http://purl.uniprot.org/citations/25678324 | http://purl.uniprot.org/core/author | "Papale A."xsd:string |
| http://purl.uniprot.org/citations/25678324 | http://purl.uniprot.org/core/author | "Trepte P."xsd:string |
| http://purl.uniprot.org/citations/25678324 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25678324 | http://purl.uniprot.org/core/name | "Cell Death Differ"xsd:string |
| http://purl.uniprot.org/citations/25678324 | http://purl.uniprot.org/core/pages | "1425-1436"xsd:string |
| http://purl.uniprot.org/citations/25678324 | http://purl.uniprot.org/core/title | "Reduced SNAP-25 increases PSD-95 mobility and impairs spine morphogenesis."xsd:string |