| http://purl.uniprot.org/citations/25678553 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25678553 | http://www.w3.org/2000/01/rdf-schema#comment | "Although it has been speculated that stem cell depletion plays a role in the rapid progression of the muscle histopathology associated with Duchenne Muscular Dystrophy (DMD), the molecular and cellular mechanisms responsible for stem cell depletion remain poorly understood. The rapid depletion of muscle stem cells has not been observed in the dystrophin-deficient model of DMD (mdx mouse), which may explain the relatively mild dystrophic phenotype observed in this animal model. In contrast, we have observed a rapid occurrence of stem cell depletion in the dystrophin/utrophin double knockout (dKO) mouse model, which exhibits histopathological features that more closely recapitulate the phenotype observed in DMD patients compared with the mdx mouse. Notch signaling has been found to be a key regulator of stem cell self-renewal and myogenesis in normal skeletal muscle; however, little is known about the role that Notch plays in the development of the dystrophic histopathology associated with DMD. Our results revealed an over-activation of Notch in the skeletal muscles of dKO mice, which correlated with sustained inflammation, impaired muscle regeneration and the rapid depletion and senescence of the muscle progenitor cells (MPCs, i.e. Pax7+ cells). Consequently, the repression of Notch in the skeletal muscle of dKO mice delayed/reduced the depletion and senescence of MPCs, and restored the myogenesis capacity while reducing inflammation and fibrosis. We suggest that the down-regulation of Notch could represent a viable approach to reduce the dystrophic histopathologies associated with DMD."xsd:string |
| http://purl.uniprot.org/citations/25678553 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/ddv055"xsd:string |
| http://purl.uniprot.org/citations/25678553 | http://purl.uniprot.org/core/author | "Lu A."xsd:string |
| http://purl.uniprot.org/citations/25678553 | http://purl.uniprot.org/core/author | "Tang Y."xsd:string |
| http://purl.uniprot.org/citations/25678553 | http://purl.uniprot.org/core/author | "Wang B."xsd:string |
| http://purl.uniprot.org/citations/25678553 | http://purl.uniprot.org/core/author | "Mu X."xsd:string |
| http://purl.uniprot.org/citations/25678553 | http://purl.uniprot.org/core/author | "Takayama K."xsd:string |
| http://purl.uniprot.org/citations/25678553 | http://purl.uniprot.org/core/author | "Weiss K."xsd:string |
| http://purl.uniprot.org/citations/25678553 | http://purl.uniprot.org/core/author | "Huard J."xsd:string |
| http://purl.uniprot.org/citations/25678553 | http://purl.uniprot.org/core/author | "Usas A."xsd:string |
| http://purl.uniprot.org/citations/25678553 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25678553 | http://purl.uniprot.org/core/name | "Hum Mol Genet"xsd:string |
| http://purl.uniprot.org/citations/25678553 | http://purl.uniprot.org/core/pages | "2923-2937"xsd:string |
| http://purl.uniprot.org/citations/25678553 | http://purl.uniprot.org/core/title | "The role of Notch signaling in muscle progenitor cell depletion and the rapid onset of histopathology in muscular dystrophy."xsd:string |
| http://purl.uniprot.org/citations/25678553 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/25678553 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25678553 |
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