| http://purl.uniprot.org/citations/25685822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25685822 | http://www.w3.org/2000/01/rdf-schema#comment | "Diabetic retinopathy (DR) is a serious complication of diabetes mellitus. This study aimed to observe the alleviation of the ethanol extract of Dendrobium chrysotoxum Lindl. (DC), a traditional Chinese herbal medicine, on DR and its engaged mechanism. After DC (30 or 300 mg/kg) was orally administrated, the breakdown of blood retinal barrier (BRB) in streptozotocin-(STZ-) induced diabetic rats was attenuated by DC. Decreased retinal mRNA expression of tight junction proteins (including occludin and claudin-1) in diabetic rats was also reversed by DC. Western blot analysis and retinal immunofluorescence staining results further confirmed that DC reversed the decreased expression of occludin and claudin-1 proteins in diabetic rats. DC reduced the increased retinal mRNA expressions of intercellular adhesion molecule-1 (ICAM-1), tumor necrosis factor α (TNFα), interleukin-(IL-) 6, and IL-1β in diabetic rats. In addition, DC alleviated the increased 1 and phosphorylated p65, IκB, and IκB kinase (IKK) in diabetic rats. DC also reduced the increased serum levels of TNFα, interferon-γ (IFN-γ), IL-6, IL-1β, IL-8, IL-12, IL-2, IL-3, and IL-10 in diabetic rats. Therefore, DC can alleviate DR by inhibiting retinal inflammation and preventing the decrease of tight junction proteins, such as occludin and claudin-1."xsd:string |
| http://purl.uniprot.org/citations/25685822 | http://purl.org/dc/terms/identifier | "doi:10.1155/2015/518317"xsd:string |
| http://purl.uniprot.org/citations/25685822 | http://purl.uniprot.org/core/author | "Yu Z."xsd:string |
| http://purl.uniprot.org/citations/25685822 | http://purl.uniprot.org/core/author | "Sheng Y."xsd:string |
| http://purl.uniprot.org/citations/25685822 | http://purl.uniprot.org/core/author | "Wang Z."xsd:string |
| http://purl.uniprot.org/citations/25685822 | http://purl.uniprot.org/core/author | "Yang L."xsd:string |
| http://purl.uniprot.org/citations/25685822 | http://purl.uniprot.org/core/author | "Lu B."xsd:string |
| http://purl.uniprot.org/citations/25685822 | http://purl.uniprot.org/core/author | "Gong C."xsd:string |
| http://purl.uniprot.org/citations/25685822 | http://purl.uniprot.org/core/author | "Ji L."xsd:string |
| http://purl.uniprot.org/citations/25685822 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25685822 | http://purl.uniprot.org/core/name | "J Diabetes Res"xsd:string |
| http://purl.uniprot.org/citations/25685822 | http://purl.uniprot.org/core/pages | "518317"xsd:string |
| http://purl.uniprot.org/citations/25685822 | http://purl.uniprot.org/core/title | "Dendrobium chrysotoxum Lindl. alleviates diabetic retinopathy by preventing retinal inflammation and tight junction protein decrease."xsd:string |
| http://purl.uniprot.org/citations/25685822 | http://purl.uniprot.org/core/volume | "2015"xsd:string |
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