| http://purl.uniprot.org/citations/25686533 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25686533 | http://www.w3.org/2000/01/rdf-schema#comment | "Cancer-associated fibroblasts play a crucial role in accelerating tumor progression, but there is a knowledge gap regarding the chemotactic signal activated in a tumor microenvironment. In this study, the expression of type IV collagen was knocked down using a lentiviral-mediated short hairpin RNA strategy. Although there was no obvious effect on cell growth in vitro, silencing the Col4-α1 gene decreased the tumorigenicity of B16F10 in C57BL/6 mice, which was accompanied by a reduction in the infiltration of alpha-smooth muscle actin-positive (α-SMA+) fibroblasts. Silencing the Col4-α1 gene or disrupting integrin engagement by blocking the antibody reduced the expression of platelet-derived growth factor A (PDGF-A), a potent chemotactic factor for fibroblasts. Furthermore, ectopic expression of the autoclustering integrin mutant significantly stimulated PDGF-A expression in murine B16F10 and human U118MG and Huh7 cells. PDGF-A-specific sh-RNA and neutralizing anti-PDGF-A antibody effectively inhibited the transwell migration of fibroblasts. Adding recombinant PDGF-A back to shCol cell-conditioned media restored the fibroblast-attraction ability indicating that PDGF-A is a major chemotactic factor for fibroblasts in the current study model. The integrin-associated PDGF-A production correlated with the activation of Src and ERK. High type IV collagen staining intensity colocalized with elevated PDGF-A expression was observed in tumor tissues obtained from hepatoma and glioma patients. The integrin signal pathway was activated by collagen engagement through Src and ERK, leading to enhanced PDGF-A production, which serves as a key regulator of fibroblast recruitment."xsd:string |
| http://purl.uniprot.org/citations/25686533 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbamcr.2015.02.004"xsd:string |
| http://purl.uniprot.org/citations/25686533 | http://purl.uniprot.org/core/author | "Lin J.S."xsd:string |
| http://purl.uniprot.org/citations/25686533 | http://purl.uniprot.org/core/author | "Lin H.C."xsd:string |
| http://purl.uniprot.org/citations/25686533 | http://purl.uniprot.org/core/author | "Chen S.Y."xsd:string |
| http://purl.uniprot.org/citations/25686533 | http://purl.uniprot.org/core/author | "Cheng Y.J."xsd:string |
| http://purl.uniprot.org/citations/25686533 | http://purl.uniprot.org/core/author | "Yang B.C."xsd:string |
| http://purl.uniprot.org/citations/25686533 | http://purl.uniprot.org/core/author | "Shan Y.S."xsd:string |
| http://purl.uniprot.org/citations/25686533 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25686533 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta"xsd:string |
| http://purl.uniprot.org/citations/25686533 | http://purl.uniprot.org/core/pages | "929-939"xsd:string |
| http://purl.uniprot.org/citations/25686533 | http://purl.uniprot.org/core/title | "Dependence of fibroblast infiltration in tumor stroma on type IV collagen-initiated integrin signal through induction of platelet-derived growth factor."xsd:string |
| http://purl.uniprot.org/citations/25686533 | http://purl.uniprot.org/core/volume | "1853"xsd:string |
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