| http://purl.uniprot.org/citations/25687759 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25687759 | http://www.w3.org/2000/01/rdf-schema#comment | "Rejection remains a major clinical challenge limiting allograft survival after solid organ transplantation. Both cellular and humoral immunity contribute to this complication, with increased recognition of Ab-mediated damage during acute and chronic rejection. Using a mouse model of MHC-mismatched heart transplantation, we report markedly protective effects of Notch inhibition, dampening both T cell and Ab-driven rejection. T cell-specific pan-Notch blockade prolonged heart allograft survival and decreased IFN-γ and IL-4 production by alloreactive T cells, especially when combined with depletion of recipient CD8(+) T cells. These effects were associated with decreased infiltration by conventional T cells and an increased proportion of regulatory T cells in the graft. Transient administration of neutralizing Abs specific for delta-like (Dll)1/4 Notch ligands in the peritransplant period led to prolonged acceptance of allogeneic hearts, with superior outcome over Notch inhibition only in T cells. Systemic Dll1/4 inhibition decreased T cell cytokines and graft infiltration, germinal center B cell and plasmablast numbers, as well as production of donor-specific alloantibodies and complement deposition in the transplanted hearts. Dll1 or Dll4 inhibition alone provided partial protection. Thus, pathogenic signals delivered by Dll1/4 Notch ligands early after transplantation promote organ rejection through several complementary mechanisms. Transient interruption of these signals represents an attractive new therapeutic strategy to enhance long-term allograft survival."xsd:string |
| http://purl.uniprot.org/citations/25687759 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1402034"xsd:string |
| http://purl.uniprot.org/citations/25687759 | http://purl.uniprot.org/core/author | "Shelton A."xsd:string |
| http://purl.uniprot.org/citations/25687759 | http://purl.uniprot.org/core/author | "Feng J."xsd:string |
| http://purl.uniprot.org/citations/25687759 | http://purl.uniprot.org/core/author | "Chung J."xsd:string |
| http://purl.uniprot.org/citations/25687759 | http://purl.uniprot.org/core/author | "Yan M."xsd:string |
| http://purl.uniprot.org/citations/25687759 | http://purl.uniprot.org/core/author | "Maillard I."xsd:string |
| http://purl.uniprot.org/citations/25687759 | http://purl.uniprot.org/core/author | "Bishop D.K."xsd:string |
| http://purl.uniprot.org/citations/25687759 | http://purl.uniprot.org/core/author | "Wood S."xsd:string |
| http://purl.uniprot.org/citations/25687759 | http://purl.uniprot.org/core/author | "Friedman A."xsd:string |
| http://purl.uniprot.org/citations/25687759 | http://purl.uniprot.org/core/author | "Siebel C.W."xsd:string |
| http://purl.uniprot.org/citations/25687759 | http://purl.uniprot.org/core/author | "Radojcic V."xsd:string |
| http://purl.uniprot.org/citations/25687759 | http://purl.uniprot.org/core/author | "Sandy-Sloat A.R."xsd:string |
| http://purl.uniprot.org/citations/25687759 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25687759 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/25687759 | http://purl.uniprot.org/core/pages | "2899-2908"xsd:string |
| http://purl.uniprot.org/citations/25687759 | http://purl.uniprot.org/core/title | "Transient blockade of delta-like Notch ligands prevents allograft rejection mediated by cellular and humoral mechanisms in a mouse model of heart transplantation."xsd:string |
| http://purl.uniprot.org/citations/25687759 | http://purl.uniprot.org/core/volume | "194"xsd:string |
| http://purl.uniprot.org/citations/25687759 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25687759 |
| http://purl.uniprot.org/citations/25687759 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25687759 |
| http://purl.uniprot.org/uniprot/#_B4YB45-mappedCitation-25687759 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25687759 |
| http://purl.uniprot.org/uniprot/#_B4YB46-mappedCitation-25687759 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25687759 |
| http://purl.uniprot.org/uniprot/#_B4YB47-mappedCitation-25687759 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25687759 |
| http://purl.uniprot.org/uniprot/#_B4YB48-mappedCitation-25687759 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25687759 |