http://purl.uniprot.org/citations/25689690 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/25689690 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundCD4(+) cell count, the common HIV infection screening test, is costly and unable to differentiate HIV monoinfection from its concurrent infection with hepatitis B or C virus. We aimed to ascertain diagnostic value of serum adenosine deaminase (ADA) activity as a useful tool to differentiate HIV mono- and co-infection.MethodsBlood samples were collected from 30 HIV-HBV and 30 HIV-HCV coinfected patients, 33 HIV positive subjects, and 72 controls. CD4(+) cell count, serum total ADA (tADA), and ADA1, and ADA2 isoenzyme activities were determined and their sensitivity and specificity were computed.ResultstADA and ADA2 activities were significantly higher and CD4(+) counts were markedly lower in all patients compared with controls. Strong inverse agreements between CD4(+) cell counts and both tADA and ADA2 activities were observed. Serum tADA and ADA1 activities showed the highest specificity and the highest sensitivity, respectively, for differentiating HIV monoinfection from HIV-HBV and HIV-HCV coinfections.ConclusionsWe showed strong agreement and correlation between CD4(+) cell count and ADA enzyme activity. Based on high ADA sensitivity and specificity, it is concluded that determination of ADA activity might be a novel diagnostic tool to distinguish of HIV monoinfection from its coinfection with HBV or HCV."xsd:string |
http://purl.uniprot.org/citations/25689690 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcla.21836"xsd:string |
http://purl.uniprot.org/citations/25689690 | http://purl.uniprot.org/core/author | "Khodadadi I."xsd:string |
http://purl.uniprot.org/citations/25689690 | http://purl.uniprot.org/core/author | "Najafi A."xsd:string |
http://purl.uniprot.org/citations/25689690 | http://purl.uniprot.org/core/author | "Rahbari R."xsd:string |
http://purl.uniprot.org/citations/25689690 | http://purl.uniprot.org/core/author | "Abdi M."xsd:string |
http://purl.uniprot.org/citations/25689690 | http://purl.uniprot.org/core/author | "Khatooni Z."xsd:string |
http://purl.uniprot.org/citations/25689690 | http://purl.uniprot.org/core/author | "Naseri N."xsd:string |
http://purl.uniprot.org/citations/25689690 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
http://purl.uniprot.org/citations/25689690 | http://purl.uniprot.org/core/name | "J Clin Lab Anal"xsd:string |
http://purl.uniprot.org/citations/25689690 | http://purl.uniprot.org/core/pages | "200-203"xsd:string |
http://purl.uniprot.org/citations/25689690 | http://purl.uniprot.org/core/title | "Serum Adenosine Deaminase (ADA) Activity: A Novel Screening Test to Differentiate HIV Monoinfection From HIV-HBV and HIV-HCV Coinfections."xsd:string |
http://purl.uniprot.org/citations/25689690 | http://purl.uniprot.org/core/volume | "30"xsd:string |
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