| http://purl.uniprot.org/citations/25691158 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25691158 | http://www.w3.org/2000/01/rdf-schema#comment | "Mycophenolic acid (MPA) is the active metabolite of mycophenolate mofetil, an effective immunosuppressive drug. Both MPA and mycophenolate mofetil are highly specific inhibitors of guanine nucleotide synthesis and of T-cell activation. However, the mechanism by which guanine nucleotide depletion suppresses T-cell activation is unknown. Depletion of GTP inhibits ribosomal RNA synthesis in T cells by inhibiting transcription initiation factor I (TIF-IA), a GTP-binding protein that recruits RNA polymerase I to the ribosomal DNA promoter. TIF-IA-GTP binds the ErbB3-binding protein 1, and together they enhance the transcription of proliferating cell nuclear antigen (PCNA). GTP binding by TIF-IA and ErbB3-binding protein 1 phosphorylation by protein kinase C δ are both required for optimal PCNA expression. The protein kinase C inhibitor sotrastaurin markedly potentiates the inhibition of ribosomal RNA synthesis, PCNA expression, and T-cell activation induced by MPA, suggesting that the combination of the two agents are more highly effective than either alone in inducing immunosuppression."xsd:string |
| http://purl.uniprot.org/citations/25691158 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2014-12-616433"xsd:string |
| http://purl.uniprot.org/citations/25691158 | http://purl.uniprot.org/core/author | "Lee Y."xsd:string |
| http://purl.uniprot.org/citations/25691158 | http://purl.uniprot.org/core/author | "Mitchell B.S."xsd:string |
| http://purl.uniprot.org/citations/25691158 | http://purl.uniprot.org/core/author | "Utz P.J."xsd:string |
| http://purl.uniprot.org/citations/25691158 | http://purl.uniprot.org/core/author | "Hamburger A.W."xsd:string |
| http://purl.uniprot.org/citations/25691158 | http://purl.uniprot.org/core/author | "Sunwoo J.B."xsd:string |
| http://purl.uniprot.org/citations/25691158 | http://purl.uniprot.org/core/author | "Urbani L."xsd:string |
| http://purl.uniprot.org/citations/25691158 | http://purl.uniprot.org/core/author | "Nguyen l.e. X.T."xsd:string |
| http://purl.uniprot.org/citations/25691158 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25691158 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
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| http://purl.uniprot.org/citations/25691158 | http://purl.uniprot.org/core/title | "Regulation of ribosomal RNA synthesis in T cells: requirement for GTP and Ebp1."xsd:string |
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