| http://purl.uniprot.org/citations/25691244 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25691244 | http://www.w3.org/2000/01/rdf-schema#comment | "Autophagosome biogenesis requires two ubiquitin-like conjugation systems. One couples ubiquitin-like Atg8 to phosphatidylethanolamine, and the other couples ubiquitin-like Atg12 to Atg5. Atg12~Atg5 then forms a heterodimer with Atg16. Membrane recruitment of the Atg12~Atg5/Atg16 complex defines the Atg8 lipidation site. Lipidation requires a PI3P-containing precursor. How PI3P is sensed and used to coordinate the conjugation systems remained unclear. Here, we show that Atg21, a WD40 β-propeller, binds via PI3P to the preautophagosomal structure (PAS). Atg21 directly interacts with the coiled-coil domain of Atg16 and with Atg8. This latter interaction requires the conserved F5K6-motif in the N-terminal helical domain of Atg8, but not its AIM-binding site. Accordingly, the Atg8 AIM-binding site remains free to mediate interaction with its E2 enzyme Atg3. Atg21 thus defines PI3P-dependently the lipidation site by linking and organising the E3 ligase complex and Atg8 at the PAS."xsd:string |
| http://purl.uniprot.org/citations/25691244 | http://purl.org/dc/terms/identifier | "doi:10.15252/embj.201488957"xsd:string |
| http://purl.uniprot.org/citations/25691244 | http://purl.uniprot.org/core/author | "Thumm M."xsd:string |
| http://purl.uniprot.org/citations/25691244 | http://purl.uniprot.org/core/author | "Krick R."xsd:string |
| http://purl.uniprot.org/citations/25691244 | http://purl.uniprot.org/core/author | "Schlotterhose P."xsd:string |
| http://purl.uniprot.org/citations/25691244 | http://purl.uniprot.org/core/author | "Juris L."xsd:string |
| http://purl.uniprot.org/citations/25691244 | http://purl.uniprot.org/core/author | "Rube P."xsd:string |
| http://purl.uniprot.org/citations/25691244 | http://purl.uniprot.org/core/author | "Montino M."xsd:string |
| http://purl.uniprot.org/citations/25691244 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25691244 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/25691244 | http://purl.uniprot.org/core/pages | "955-973"xsd:string |
| http://purl.uniprot.org/citations/25691244 | http://purl.uniprot.org/core/title | "PI3P binding by Atg21 organises Atg8 lipidation."xsd:string |
| http://purl.uniprot.org/citations/25691244 | http://purl.uniprot.org/core/volume | "34"xsd:string |
| http://purl.uniprot.org/citations/25691244 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25691244 |
| http://purl.uniprot.org/citations/25691244 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25691244 |
| http://purl.uniprot.org/uniprot/Q02887#attribution-C19B0AA9EF2B85FCFC7092E7AFF2CAA0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25691244 |
| http://purl.uniprot.org/uniprot/Q02887#attribution-D40B2AD99F63113A631938FD52B1DA7F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25691244 |
| http://purl.uniprot.org/uniprot/#_P53867-mappedCitation-25691244 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25691244 |
| http://purl.uniprot.org/uniprot/#_A0A8H4BU44-mappedCitation-25691244 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25691244 |
| http://purl.uniprot.org/uniprot/#_A0A6A5PZP1-mappedCitation-25691244 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25691244 |
| http://purl.uniprot.org/uniprot/#_P38182-mappedCitation-25691244 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25691244 |
| http://purl.uniprot.org/uniprot/#_P38270-mappedCitation-25691244 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25691244 |
| http://purl.uniprot.org/uniprot/#_Q03818-mappedCitation-25691244 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25691244 |
| http://purl.uniprot.org/uniprot/#_P07267-mappedCitation-25691244 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25691244 |