| http://purl.uniprot.org/citations/25692705 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25692705 | http://www.w3.org/2000/01/rdf-schema#comment | "Dysfunction in Ataxia-telangiectasia mutated (ATM), a central component of the DNA repair machinery, results in Ataxia Telangiectasia (AT), a cancer-prone disease with a variety of inflammatory manifestations. By analyzing AT patient samples and Atm(-/-) mice, we found that unrepaired DNA lesions induce type I interferons (IFNs), resulting in enhanced anti-viral and anti-bacterial responses in Atm(-/-) mice. Priming of the type I interferon system by DNA damage involved release of DNA into the cytoplasm where it activated the cytosolic DNA sensing STING-mediated pathway, which in turn enhanced responses to innate stimuli by activating the expression of Toll-like receptors, RIG-I-like receptors, cytoplasmic DNA sensors, and their downstream signaling partners. This study provides a potential explanation for the inflammatory phenotype of AT patients and establishes damaged DNA as a cell intrinsic danger signal that primes the innate immune system for a rapid and amplified response to microbial and environmental threats."xsd:string |
| http://purl.uniprot.org/citations/25692705 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2015.01.012"xsd:string |
| http://purl.uniprot.org/citations/25692705 | http://purl.uniprot.org/core/author | "Weiss S."xsd:string |
| http://purl.uniprot.org/citations/25692705 | http://purl.uniprot.org/core/author | "Nilsson J.A."xsd:string |
| http://purl.uniprot.org/citations/25692705 | http://purl.uniprot.org/core/author | "Lienenklaus S."xsd:string |
| http://purl.uniprot.org/citations/25692705 | http://purl.uniprot.org/core/author | "Gekara N.O."xsd:string |
| http://purl.uniprot.org/citations/25692705 | http://purl.uniprot.org/core/author | "Nilsson L.M."xsd:string |
| http://purl.uniprot.org/citations/25692705 | http://purl.uniprot.org/core/author | "Kroger A."xsd:string |
| http://purl.uniprot.org/citations/25692705 | http://purl.uniprot.org/core/author | "Resch U."xsd:string |
| http://purl.uniprot.org/citations/25692705 | http://purl.uniprot.org/core/author | "Anugula S."xsd:string |
| http://purl.uniprot.org/citations/25692705 | http://purl.uniprot.org/core/author | "Erttmann S.F."xsd:string |
| http://purl.uniprot.org/citations/25692705 | http://purl.uniprot.org/core/author | "Ek T."xsd:string |
| http://purl.uniprot.org/citations/25692705 | http://purl.uniprot.org/core/author | "Hartlova A."xsd:string |
| http://purl.uniprot.org/citations/25692705 | http://purl.uniprot.org/core/author | "Raffi F.A."xsd:string |
| http://purl.uniprot.org/citations/25692705 | http://purl.uniprot.org/core/author | "Schmalz A.M."xsd:string |
| http://purl.uniprot.org/citations/25692705 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25692705 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/25692705 | http://purl.uniprot.org/core/pages | "332-343"xsd:string |
| http://purl.uniprot.org/citations/25692705 | http://purl.uniprot.org/core/title | "DNA damage primes the type I interferon system via the cytosolic DNA sensor STING to promote anti-microbial innate immunity."xsd:string |
| http://purl.uniprot.org/citations/25692705 | http://purl.uniprot.org/core/volume | "42"xsd:string |
| http://purl.uniprot.org/citations/25692705 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25692705 |
| http://purl.uniprot.org/citations/25692705 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25692705 |
| http://purl.uniprot.org/uniprot/#_A0A125R9I3-mappedCitation-25692705 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25692705 |
| http://purl.uniprot.org/uniprot/#_D3Z0Q2-mappedCitation-25692705 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25692705 |