| http://purl.uniprot.org/citations/25697138 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25697138 | http://www.w3.org/2000/01/rdf-schema#comment | "Nonconventional innate memory CD8(+) T cells characteristically expressing CD44, CD122, eomesodermin (Eomes) and promyelocytic leukemia zinc finger (PLZF) were derived in culture from CD4(+)CD8(+) double positive (DP) thymocytes of normal BALB/c and C57BL/6 mice. These culture-differentiated cells constitutively express toll-like receptor (TLR)4 and release interferon (IFN)-γ and interleukin (IL)-10. We show the TLR4-ligand lipopolysaccharide (LPS) stimulate the TLR and up-regulate IFN-γ skewing the cells towards type 1 polarization. In presence of LPS these cells also express suppressor of cytokine signaling (SOCS)1 and thus suppress IL-10 expression. In contrast, heat shock protein (Hsp)70 down-regulated TLR4 augmenting the anti-inflammatory cytokine IL-10. In association with IL-10 release IFN-γ was abrogated. The programmed cell death (PD)-1 mostly present in regulatory T cells was stimulated in these IL-10 producing cells by Hsp70 and not LPS indicating the cells can be driven to two contrast outcomes by the two TLR4 ligands. Our work provides a scope for in vitro monitoring of CD8(+) T cells to decipher important immune therapeutic option during infection or sepsis."xsd:string |
| http://purl.uniprot.org/citations/25697138 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cyto.2015.01.018"xsd:string |
| http://purl.uniprot.org/citations/25697138 | http://purl.uniprot.org/core/author | "Mukherjee S."xsd:string |
| http://purl.uniprot.org/citations/25697138 | http://purl.uniprot.org/core/author | "Ghosh A.K."xsd:string |
| http://purl.uniprot.org/citations/25697138 | http://purl.uniprot.org/core/author | "Biswas T."xsd:string |
| http://purl.uniprot.org/citations/25697138 | http://purl.uniprot.org/core/author | "Sinha D."xsd:string |
| http://purl.uniprot.org/citations/25697138 | http://purl.uniprot.org/core/author | "Biswas R."xsd:string |
| http://purl.uniprot.org/citations/25697138 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25697138 | http://purl.uniprot.org/core/name | "Cytokine"xsd:string |
| http://purl.uniprot.org/citations/25697138 | http://purl.uniprot.org/core/pages | "44-52"xsd:string |
| http://purl.uniprot.org/citations/25697138 | http://purl.uniprot.org/core/title | "LPS stimulates and Hsp70 down-regulates TLR4 to orchestrate differential cytokine response of culture-differentiated innate memory CD8(+) T cells."xsd:string |
| http://purl.uniprot.org/citations/25697138 | http://purl.uniprot.org/core/volume | "73"xsd:string |
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