| http://purl.uniprot.org/citations/25699710 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25699710 | http://www.w3.org/2000/01/rdf-schema#comment | "The mechanisms contributing to transcription-associated genomic instability are both complex and incompletely understood. Although R-loops are normal transcriptional intermediates, they are also associated with genomic instability. Here, we show that BRCA1 is recruited to R-loops that form normally over a subset of transcription termination regions. There it mediates the recruitment of a specific, physiological binding partner, senataxin (SETX). Disruption of this complex led to R-loop-driven DNA damage at those loci as reflected by adjacent γ-H2AX accumulation and ssDNA breaks within the untranscribed strand of relevant R-loop structures. Genome-wide analysis revealed widespread BRCA1 binding enrichment at R-loop-rich termination regions (TRs) of actively transcribed genes. Strikingly, within some of these genes in BRCA1 null breast tumors, there are specific insertion/deletion mutations located close to R-loop-mediated BRCA1 binding sites within TRs. Thus, BRCA1/SETX complexes support a DNA repair mechanism that addresses R-loop-based DNA damage at transcriptional pause sites."xsd:string |
| http://purl.uniprot.org/citations/25699710 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2015.01.011"xsd:string |
| http://purl.uniprot.org/citations/25699710 | http://purl.uniprot.org/core/author | "Parmigiani G."xsd:string |
| http://purl.uniprot.org/citations/25699710 | http://purl.uniprot.org/core/author | "Kellis M."xsd:string |
| http://purl.uniprot.org/citations/25699710 | http://purl.uniprot.org/core/author | "Livingston D.M."xsd:string |
| http://purl.uniprot.org/citations/25699710 | http://purl.uniprot.org/core/author | "Hill S.J."xsd:string |
| http://purl.uniprot.org/citations/25699710 | http://purl.uniprot.org/core/author | "Dimitrov S."xsd:string |
| http://purl.uniprot.org/citations/25699710 | http://purl.uniprot.org/core/author | "Yen A."xsd:string |
| http://purl.uniprot.org/citations/25699710 | http://purl.uniprot.org/core/author | "Proudfoot N.J."xsd:string |
| http://purl.uniprot.org/citations/25699710 | http://purl.uniprot.org/core/author | "Pathania S."xsd:string |
| http://purl.uniprot.org/citations/25699710 | http://purl.uniprot.org/core/author | "Kamieniarz-Gdula K."xsd:string |
| http://purl.uniprot.org/citations/25699710 | http://purl.uniprot.org/core/author | "Skourti-Stathaki K."xsd:string |
| http://purl.uniprot.org/citations/25699710 | http://purl.uniprot.org/core/author | "Hatchi E."xsd:string |
| http://purl.uniprot.org/citations/25699710 | http://purl.uniprot.org/core/author | "Pinello L."xsd:string |
| http://purl.uniprot.org/citations/25699710 | http://purl.uniprot.org/core/author | "Eaton M.L."xsd:string |
| http://purl.uniprot.org/citations/25699710 | http://purl.uniprot.org/core/author | "McKinney K.M."xsd:string |
| http://purl.uniprot.org/citations/25699710 | http://purl.uniprot.org/core/author | "Ventz S."xsd:string |
| http://purl.uniprot.org/citations/25699710 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25699710 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/25699710 | http://purl.uniprot.org/core/pages | "636-647"xsd:string |
| http://purl.uniprot.org/citations/25699710 | http://purl.uniprot.org/core/title | "BRCA1 recruitment to transcriptional pause sites is required for R-loop-driven DNA damage repair."xsd:string |
| http://purl.uniprot.org/citations/25699710 | http://purl.uniprot.org/core/volume | "57"xsd:string |
| http://purl.uniprot.org/citations/25699710 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25699710 |
| http://purl.uniprot.org/citations/25699710 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25699710 |