Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/25701228http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/25701228http://www.w3.org/2000/01/rdf-schema#comment"The cytosolic factor Saccharomyces cerevisiae-like 1 (SEC14L1) is a regulator of lipid metabolism and signaling pathways that has been suggested to play a role in cancer. To learn more about its relevance for prostate cancer, SEC14L1 expression was analyzed on a tissue microarray containing samples from 11152 prostate cancer patients. In benign prostate glands, SEC14L1 immunostaining was absent or weak. In prostate cancer, SEC14L1 positivity was found in 80% of 9876 interpretable tumors including 9% with strong, 38% with moderate, and 32% with weak immunostaining. SEC14L1 expression was more frequent in Transmembrane Protease, Serine 2 (TMPRSS2):Ets-related gene (ERG) fusion-positive (89%) than in TMPSSR2:ERG-negative cancers (73%, P < .0001). Comparative analysis of SEC14L1 expression in TMPSSR2:ERG-positive and -negative cancers suggested a different role of SEC14L1 in the 2 subsets: in TMPSSR2:ERG-negative cancers, strong SEC14L1 expression was associated with early prostate-specific antigen recurrence (P = .0270), advanced tumor stage (P = .0042), high Gleason score (P < .0001), and high preoperative prostate-specific antigen levels (P = .0035). In TMPSSR2:ERG-positive cancers, strong SEC14L1 staining was linked to a prolonged recurrence-free interval (P = .0023) and absence of lymph node metastases (P = .0002). Strong associations of high SEC14L1 levels with chromosomal deletions (5q, 6q, phosphatase and tensin homolog gene, 3p13; P < .0001) and a high Ki-67 labeling index (P < .0001) were seen in TMPSSR2:ERG-negative but not TMPSSR2:ERG-positive cancers. A direct or indirect role of SEC14L1 in maintenance of genomic integrity and regulating cell proliferation may thus exclusively exist in TMPSSR2:ERG-negative cancers. In conclusion, our data suggest a markedly different role of SEC14L1 in TMPSSR2:ERG-negative and TMPSSR2:ERG-positive prostate cancers."xsd:string
http://purl.uniprot.org/citations/25701228http://purl.org/dc/terms/identifier"doi:10.1016/j.humpath.2014.06.006"xsd:string
http://purl.uniprot.org/citations/25701228http://purl.uniprot.org/core/author"Simon R."xsd:string
http://purl.uniprot.org/citations/25701228http://purl.uniprot.org/core/author"Adam M."xsd:string
http://purl.uniprot.org/citations/25701228http://purl.uniprot.org/core/author"Sauter G."xsd:string
http://purl.uniprot.org/citations/25701228http://purl.uniprot.org/core/author"Burdelski C."xsd:string
http://purl.uniprot.org/citations/25701228http://purl.uniprot.org/core/author"Minner S."xsd:string
http://purl.uniprot.org/citations/25701228http://purl.uniprot.org/core/author"Steurer S."xsd:string
http://purl.uniprot.org/citations/25701228http://purl.uniprot.org/core/author"Huland H."xsd:string
http://purl.uniprot.org/citations/25701228http://purl.uniprot.org/core/author"Wittmer C."xsd:string
http://purl.uniprot.org/citations/25701228http://purl.uniprot.org/core/author"Quaas A."xsd:string
http://purl.uniprot.org/citations/25701228http://purl.uniprot.org/core/author"Graefen M."xsd:string
http://purl.uniprot.org/citations/25701228http://purl.uniprot.org/core/author"Schlomm T."xsd:string
http://purl.uniprot.org/citations/25701228http://purl.uniprot.org/core/author"Koop C."xsd:string
http://purl.uniprot.org/citations/25701228http://purl.uniprot.org/core/author"Tsourlakis M.C."xsd:string
http://purl.uniprot.org/citations/25701228http://purl.uniprot.org/core/author"Heinzer H."xsd:string
http://purl.uniprot.org/citations/25701228http://purl.uniprot.org/core/author"Hube-Magg C."xsd:string
http://purl.uniprot.org/citations/25701228http://purl.uniprot.org/core/author"Barreau Y."xsd:string
http://purl.uniprot.org/citations/25701228http://purl.uniprot.org/core/date"2015"xsd:gYear
http://purl.uniprot.org/citations/25701228http://purl.uniprot.org/core/name"Hum Pathol"xsd:string
http://purl.uniprot.org/citations/25701228http://purl.uniprot.org/core/pages"514-523"xsd:string
http://purl.uniprot.org/citations/25701228http://purl.uniprot.org/core/title"Saccharomyces cerevisiae-like 1 overexpression is frequent in prostate cancer and has markedly different effects in Ets-related gene fusion-positive and fusion-negative cancers."xsd:string
http://purl.uniprot.org/citations/25701228http://purl.uniprot.org/core/volume"46"xsd:string
http://purl.uniprot.org/citations/25701228http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/25701228
▶