| http://purl.uniprot.org/citations/25701787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25701787 | http://www.w3.org/2000/01/rdf-schema#comment | "Heterogeneous nuclear ribonucleoprotein K (hnRNP K) is a multi-functional protein involved in transcription, mRNA splicing, mRNA stabilization and translation. Although hnRNP K has been suggested to play a role in the development of many cancers, its molecular function in colorectal cancer has remained elusive. Here we show that hnRNP K plays an important role in the mitotic process in HCT116 colon cancer cells. Furthermore, we demonstrate that hnRNP K directly transactivates the NUF2 gene, the product of which is a component of the NDC80 kinetochore complex and which is known to be critical for a stable spindle microtubule-kinetochore attachment. In addition, knockdown of both hnRNP K and NUF2 caused failure in metaphase chromosome alignment and drastic decrease in the growth of colon cancer cells. These results suggest that the hnRNP K-NUF2 axis is important for the mitotic process and proliferation of colon cancer cells and that this axis could be a target for the therapy of colon cancer."xsd:string |
| http://purl.uniprot.org/citations/25701787 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2015.02.043"xsd:string |
| http://purl.uniprot.org/citations/25701787 | http://purl.uniprot.org/core/author | "Takeda Y."xsd:string |
| http://purl.uniprot.org/citations/25701787 | http://purl.uniprot.org/core/author | "Akiyama T."xsd:string |
| http://purl.uniprot.org/citations/25701787 | http://purl.uniprot.org/core/author | "Kawasaki Y."xsd:string |
| http://purl.uniprot.org/citations/25701787 | http://purl.uniprot.org/core/author | "Kurimoto A."xsd:string |
| http://purl.uniprot.org/citations/25701787 | http://purl.uniprot.org/core/author | "Taniue K."xsd:string |
| http://purl.uniprot.org/citations/25701787 | http://purl.uniprot.org/core/author | "Sugimasa H."xsd:string |
| http://purl.uniprot.org/citations/25701787 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25701787 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/25701787 | http://purl.uniprot.org/core/pages | "29-35"xsd:string |
| http://purl.uniprot.org/citations/25701787 | http://purl.uniprot.org/core/title | "Heterogeneous nuclear ribonucleoprotein K upregulates the kinetochore complex component NUF2 and promotes the tumorigenicity of colon cancer cells."xsd:string |
| http://purl.uniprot.org/citations/25701787 | http://purl.uniprot.org/core/volume | "459"xsd:string |
| http://purl.uniprot.org/citations/25701787 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25701787 |
| http://purl.uniprot.org/citations/25701787 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25701787 |
| http://purl.uniprot.org/uniprot/#_B4DFF1-mappedCitation-25701787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25701787 |
| http://purl.uniprot.org/uniprot/#_B3KU16-mappedCitation-25701787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25701787 |
| http://purl.uniprot.org/uniprot/#_B4DUQ1-mappedCitation-25701787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25701787 |
| http://purl.uniprot.org/uniprot/#_P61978-mappedCitation-25701787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25701787 |
| http://purl.uniprot.org/uniprot/#_Q5EC54-mappedCitation-25701787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25701787 |
| http://purl.uniprot.org/uniprot/#_Q9BZD4-mappedCitation-25701787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25701787 |
| http://purl.uniprot.org/uniprot/B4DUQ1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25701787 |
| http://purl.uniprot.org/uniprot/B3KU16 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25701787 |
| http://purl.uniprot.org/uniprot/P61978 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25701787 |