| http://purl.uniprot.org/citations/25703348 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25703348 | http://www.w3.org/2000/01/rdf-schema#comment | "Gametogenesis is dependent on the expression of germline-specific genes. However, it remains unknown how the germline epigenome is distinctly established from that of somatic lineages. Here we show that genes commonly expressed in somatic lineages and spermatogenesis-progenitor cells undergo repression in a genome-wide manner in late stages of the male germline and identify underlying mechanisms. SCML2, a germline-specific subunit of a Polycomb repressive complex 1 (PRC1), establishes the unique epigenome of the male germline through two distinct antithetical mechanisms. SCML2 works with PRC1 and promotes RNF2-dependent ubiquitination of H2A, thereby marking somatic/progenitor genes on autosomes for repression. Paradoxically, SCML2 also prevents RNF2-dependent ubiquitination of H2A on sex chromosomes during meiosis, thereby enabling unique epigenetic programming of sex chromosomes for male reproduction. Our results reveal divergent mechanisms involving a shared regulator by which the male germline epigenome is distinguished from that of the soma and progenitor cells."xsd:string |
| http://purl.uniprot.org/citations/25703348 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2015.01.014"xsd:string |
| http://purl.uniprot.org/citations/25703348 | http://purl.uniprot.org/core/author | "Hasegawa K."xsd:string |
| http://purl.uniprot.org/citations/25703348 | http://purl.uniprot.org/core/author | "Zhang F."xsd:string |
| http://purl.uniprot.org/citations/25703348 | http://purl.uniprot.org/core/author | "Broering T.J."xsd:string |
| http://purl.uniprot.org/citations/25703348 | http://purl.uniprot.org/core/author | "Namekawa S.H."xsd:string |
| http://purl.uniprot.org/citations/25703348 | http://purl.uniprot.org/core/author | "Sin H.S."xsd:string |
| http://purl.uniprot.org/citations/25703348 | http://purl.uniprot.org/core/author | "Greis K.D."xsd:string |
| http://purl.uniprot.org/citations/25703348 | http://purl.uniprot.org/core/author | "Andreassen P.R."xsd:string |
| http://purl.uniprot.org/citations/25703348 | http://purl.uniprot.org/core/author | "Ichijima Y."xsd:string |
| http://purl.uniprot.org/citations/25703348 | http://purl.uniprot.org/core/author | "Bacon W.C."xsd:string |
| http://purl.uniprot.org/citations/25703348 | http://purl.uniprot.org/core/author | "Barski A."xsd:string |
| http://purl.uniprot.org/citations/25703348 | http://purl.uniprot.org/core/author | "Maezawa S."xsd:string |
| http://purl.uniprot.org/citations/25703348 | http://purl.uniprot.org/core/author | "Kartashov A.V."xsd:string |
| http://purl.uniprot.org/citations/25703348 | http://purl.uniprot.org/core/author | "Alavattam K.G."xsd:string |
| http://purl.uniprot.org/citations/25703348 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25703348 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/25703348 | http://purl.uniprot.org/core/pages | "574-588"xsd:string |
| http://purl.uniprot.org/citations/25703348 | http://purl.uniprot.org/core/title | "SCML2 establishes the male germline epigenome through regulation of histone H2A ubiquitination."xsd:string |
| http://purl.uniprot.org/citations/25703348 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/25703348 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25703348 |
| http://purl.uniprot.org/citations/25703348 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25703348 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JDY9-mappedCitation-25703348 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25703348 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGA9-mappedCitation-25703348 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25703348 |