Results

RDF/XMLNTriplesTurtleShow queryShare
SubjectPredicateObject
http://purl.uniprot.org/citations/25703835http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/25703835http://www.w3.org/2000/01/rdf-schema#comment"

Background

Enhanced generation of reactive oxygen species and increased oxidative-induced DNA damage have been identified as possible contributors to atherosclerosis. The base excision repair (BER) pathway is the principal mechanism by which mammalian cells repair oxidative DNA damage. BER deficiency can potentially accelerate atherogenesis.

Methods

We evaluated the association of Single Nucleotide Polymorphisms (SNPs) in genes encoding four different BER proteins (NEIL3, OGG1, APEX1 and XRCC1) with the incidence of myocardial infarction in a nested case-control study among participants of the second survey of the HUNT Study. The study population included 1624 cases and 4087 age- and sex-matched controls.

Results

For the NEIL3 SNP rs12645561, the TT genotype was associated with increased risk of MI (OR 1.47, 95% CI 1.02-2.12, p uncorrected for multiple comparisons = 0.04) both in the genotypic test (compared to the CC genotype) and in the recessive genetic model (compared to the CC and CT genotypes combined). For the other two NEIL3 SNPs (rs10013040 and rs1395479) and for the SNPs of OGG1 (rs1052133), APEX1 (rs1878703) and XRCC1 (rs25489) we observed no association with risk of myocardial infarction.

Conclusion

We found that the NEIL3 rs12645561 SNP TT genotype was associated with increased risk of myocardial infarction. If confirmed in other studies, this association may suggest a possible role of attenuated DNA repair, and NEIL3 in particular, in atherogenesis."xsd:string
http://purl.uniprot.org/citations/25703835http://purl.org/dc/terms/identifier"doi:10.1016/j.dnarep.2015.01.013"xsd:string
http://purl.uniprot.org/citations/25703835http://purl.uniprot.org/core/author"Wang W."xsd:string
http://purl.uniprot.org/citations/25703835http://purl.uniprot.org/core/author"Bjoras M."xsd:string
http://purl.uniprot.org/citations/25703835http://purl.uniprot.org/core/author"Luna L."xsd:string
http://purl.uniprot.org/citations/25703835http://purl.uniprot.org/core/author"Aukrust P."xsd:string
http://purl.uniprot.org/citations/25703835http://purl.uniprot.org/core/author"Halvorsen B."xsd:string
http://purl.uniprot.org/citations/25703835http://purl.uniprot.org/core/author"Damas J.K."xsd:string
http://purl.uniprot.org/citations/25703835http://purl.uniprot.org/core/author"Janszky I."xsd:string
http://purl.uniprot.org/citations/25703835http://purl.uniprot.org/core/author"Vatten L.J."xsd:string
http://purl.uniprot.org/citations/25703835http://purl.uniprot.org/core/author"Platou C.G."xsd:string
http://purl.uniprot.org/citations/25703835http://purl.uniprot.org/core/author"Laugsand L.E."xsd:string
http://purl.uniprot.org/citations/25703835http://purl.uniprot.org/core/author"Asvold B.O."xsd:string
http://purl.uniprot.org/citations/25703835http://purl.uniprot.org/core/author"Skarpengland T."xsd:string
http://purl.uniprot.org/citations/25703835http://purl.uniprot.org/core/date"2015"xsd:gYear
http://purl.uniprot.org/citations/25703835http://purl.uniprot.org/core/name"DNA Repair (Amst)"xsd:string
http://purl.uniprot.org/citations/25703835http://purl.uniprot.org/core/pages"21-27"xsd:string
http://purl.uniprot.org/citations/25703835http://purl.uniprot.org/core/title"Genetic variants in the DNA repair gene NEIL3 and the risk of myocardial infarction in a nested case-control study. The HUNT Study."xsd:string
http://purl.uniprot.org/citations/25703835http://purl.uniprot.org/core/volume"28"xsd:string
http://purl.uniprot.org/citations/25703835http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/25703835
http://purl.uniprot.org/citations/25703835http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/25703835
http://purl.uniprot.org/uniprot/#_Q8TAT5-mappedCitation-25703835http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/25703835
http://purl.uniprot.org/uniprot/Q8TAT5http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/25703835