| http://purl.uniprot.org/citations/25706655 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25706655 | http://www.w3.org/2000/01/rdf-schema#comment | "One exercise session can improve subsequent insulin-stimulated glucose uptake by skeletal muscle in healthy and insulin-resistant individuals. Our first aim was to determine whether a brief (2 weeks) high-fat diet (HFD) that caused muscle insulin resistance would activate the mammalian target of rapamycin complex 1 (mTORC1) and/or inhibitor of κB kinase/nuclear factor κB (IKK/NF-κB) pathways, which are potentially linked to induction of insulin resistance. Our second aim was to determine whether acute exercise that improved insulin-stimulated glucose uptake by muscles would attenuate activation of these pathways. We compared HFD-fed rats with rats fed a low-fat diet (LFD). Some animals from each diet group were sedentary and others were studied 3 h postexercise, when insulin-stimulated glucose uptake was increased. The results did not provide evidence that brief HFD activated either the mTORC1 (including phosphorylation of mTOR(Ser2448), TSC2(Ser939), p70S6K(Thr412), and RPS6(Ser235/236)) or the IKK/NF-κB (including abundance of IκBα or phosphorylation of NF-κB(Ser536), IKKα/β(Ser177/181), and IκB(Ser32)) pathway in insulin-resistant muscles. Exercise did not oppose the activation of either pathway, as evidenced by no attenuation of phosphorylation of key proteins in the IKK/NF-κB pathway (NF-κB(Ser536), IKKα/β(Ser177/181), and IκB(Ser32)), unaltered IκBα abundance, and no attenuation of phosphorylation of key proteins in the mTORC1 pathway (mTOR(Ser2448), TSC2(Ser939), and RPS6(Ser235/236)). Instead, exercise induced greater phosphorylation of 2 proteins of the mTORC1 pathway (PRAS40(Thr246) and p70S6K(Thr412)) in insulin-stimulated muscles, regardless of diet. Insulin resistance induced by a brief HFD was not attributable to greater activation of the mTORC1 or the IKK/NF-κB pathway in muscle, and exercise-induced improvement in insulin sensitivity was not attributable to attenuated activation of these pathways in muscle."xsd:string |
| http://purl.uniprot.org/citations/25706655 | http://purl.org/dc/terms/identifier | "doi:10.1139/apnm-2014-0412"xsd:string |
| http://purl.uniprot.org/citations/25706655 | http://purl.uniprot.org/core/author | "Sharma N."xsd:string |
| http://purl.uniprot.org/citations/25706655 | http://purl.uniprot.org/core/author | "Castorena C.M."xsd:string |
| http://purl.uniprot.org/citations/25706655 | http://purl.uniprot.org/core/author | "Cartee G.D."xsd:string |
| http://purl.uniprot.org/citations/25706655 | http://purl.uniprot.org/core/author | "Arias E.B."xsd:string |
| http://purl.uniprot.org/citations/25706655 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25706655 | http://purl.uniprot.org/core/name | "Appl Physiol Nutr Metab"xsd:string |
| http://purl.uniprot.org/citations/25706655 | http://purl.uniprot.org/core/pages | "251-262"xsd:string |
| http://purl.uniprot.org/citations/25706655 | http://purl.uniprot.org/core/title | "Effects of a brief high-fat diet and acute exercise on the mTORC1 and IKK/NF-kappaB pathways in rat skeletal muscle."xsd:string |
| http://purl.uniprot.org/citations/25706655 | http://purl.uniprot.org/core/volume | "40"xsd:string |
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