| http://purl.uniprot.org/citations/25706994 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25706994 | http://www.w3.org/2000/01/rdf-schema#comment | "It was reported recently that male mice lacking brain serotonin (5-HT) lose their preference for females (Liu et al., 2011, Nature, 472, 95-100), suggesting a role for 5-HT signaling in sexual preference. Regulation of sex preference by 5-HT lies outside of the well established roles in this behavior established for the vomeronasal organ (VNO) and the main olfactory epithelium (MOE). Presently, mice with a null mutation in the gene for tryptophan hydroxylase 2 (TPH2), which are depleted of brain 5-HT, were tested for sexual preference. When presented with inanimate (urine scents from male or estrous female) or animate (male or female mouse in estrus) sexual stimuli, TPH2-/-males show a clear preference for female over male stimuli. When a TPH2-/-male is offered the simultaneous choice between an estrous female and a male mouse, no sexual preference is expressed. However, when confounding behaviors that are seen among 3 mice in the same cage are controlled, TPH2-/-mice, like their TPH2+/+ counterparts, express a clear preference for female mice. Female TPH2-/-mice are preferred by males over TPH2+/+ females but this does not lead to increased pregnancy success. In fact, if one or both partners in a mating pair are TPH2-/-in genotype, pregnancy success rates are significantly decreased. Finally, expression of the VNO-specific cation channel TRPC2 and of CNGA2 in the MOE of TPH2-/-mice is normal, consistent with behavioral findings that sexual preference of TPH2-/-males for females is intact. In conclusion, 5-HT signaling in brain does not determine sexual preference in male mice. The use of pharmacological agents that are non-selective for the 5-HT neuronal system and that have serious adverse effects may have contributed historically to the stance that 5-HT regulates sexual behavior, including sex partner preference."xsd:string |
| http://purl.uniprot.org/citations/25706994 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0118603"xsd:string |
| http://purl.uniprot.org/citations/25706994 | http://purl.uniprot.org/core/author | "Kane M.J."xsd:string |
| http://purl.uniprot.org/citations/25706994 | http://purl.uniprot.org/core/author | "Francescutti D.M."xsd:string |
| http://purl.uniprot.org/citations/25706994 | http://purl.uniprot.org/core/author | "Kuhn D.M."xsd:string |
| http://purl.uniprot.org/citations/25706994 | http://purl.uniprot.org/core/author | "Sykes C.E."xsd:string |
| http://purl.uniprot.org/citations/25706994 | http://purl.uniprot.org/core/author | "Angoa-Perez M."xsd:string |
| http://purl.uniprot.org/citations/25706994 | http://purl.uniprot.org/core/author | "Anneken J.H."xsd:string |
| http://purl.uniprot.org/citations/25706994 | http://purl.uniprot.org/core/author | "Herrera-Mundo N."xsd:string |
| http://purl.uniprot.org/citations/25706994 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25706994 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/25706994 | http://purl.uniprot.org/core/pages | "e0118603"xsd:string |
| http://purl.uniprot.org/citations/25706994 | http://purl.uniprot.org/core/title | "Brain serotonin signaling does not determine sexual preference in male mice."xsd:string |
| http://purl.uniprot.org/citations/25706994 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/25706994 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25706994 |
| http://purl.uniprot.org/citations/25706994 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25706994 |
| http://purl.uniprot.org/uniprot/#_Q8CGV2-mappedCitation-25706994 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25706994 |
| http://purl.uniprot.org/uniprot/Q8CGV2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25706994 |